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Electroconvulsive Therapy01:30

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Electroconvulsive therapy (ECT), or shock therapy, remains a critical biomedical intervention for severe, treatment-resistant depression. While its origins can be traced back to Hippocrates' observations that malaria-induced convulsions alleviated mental illness, modern ECT has evolved significantly from its earlier, more primitive applications. First introduced in 1938 by Ugo Cerletti and his colleagues, ECT involves inducing controlled seizures using electrical currents. In its early years,...
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Updated: Jul 10, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
04:29

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[Electroconvulsive therapy in therapy-resistant mania. A case study].

M E C Neve1, J Huyser, J H Eshuis

  • 1AMC de Meren, ambulant centrum Nienoord, Nienoord 2, 1112 XG Diemen. m.e.neve@amc.uva.nl

Tijdschrift Voor Psychiatrie
|November 13, 2007
PubMed
Summary

Electroconvulsive therapy (ECT) offers rapid improvement for therapy-resistant manic symptoms. This case study shows ECT effectively treated a patient with severe mania who did not respond to medication.

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Area of Science:

  • Psychiatry and Behavioral Sciences
  • Neuroscience
  • Pharmacology

Background:

  • First manic episodes can present with severe, disruptive symptoms.
  • Treatment-resistant mania poses significant challenges in clinical practice.
  • Pharmacological interventions like olanzapine, clorazepate, and lithium may be insufficient for some patients.

Observation:

  • A 25-year-old woman exhibited suicidal and chaotic behavior during her first manic episode, necessitating 6 weeks of separation.
  • Her condition did not adequately respond to a combination of olanzapine, clorazepate, and lithium therapy.

Findings:

  • A single session of electroconvulsive therapy (ECT) led to significant improvement, eliminating the need for isolation.
  • Within approximately 4 weeks, the patient's mental state improved considerably, allowing for a reduction in medication and transfer to outpatient care.

Implications:

  • Electroconvulsive therapy (ECT) is a viable and rapid treatment option for therapy-resistant manic symptoms.
  • Early intervention with ECT may shorten hospitalization durations and facilitate smoother transitions to outpatient management.