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Updated: Jul 10, 2026

Vagus Nerve Stimulation As an Adjunctive Neurostimulation Tool in Treatment-resistant Depression
Published on: January 7, 2019
[Electroconvulsive therapy in therapy-resistant mania. A case study]
M E C Neve1, J Huyser, J H Eshuis
1AMC de Meren, ambulant centrum Nienoord, Nienoord 2, 1112 XG Diemen. m.e.neve@amc.uva.nl
Abstract:
A 25-year-old woman was separated for 6 weeks on account of her suicidal and chaotic behaviour occurring within the framework of a first manic episode. Her response to medication (olanzapine 20 mg, clorazepate 50 mg and lithium (serum level 0.9 mmol/l)) was inadequate. After only one ect treatment her condition had improved to such an extent that she no longer needed to be isolated. After about 4 weeks her mental condition was reasonably good; her medication consisted only of 10 mg of olanzapine and she could be transferred to out-patient care. ect can bring about rapid improvement in patients with therapy-resistant manic symptoms.
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