Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Picoliter viscometry using optically rotated particles.

Simon J Parkin¹, Gregor Knöner, Timo A Nieminen

¹Centre for Biophotonics and Laser Science, School of Physical Sciences, The University of Queensland, Brisbane, Queensland 4072, Australia.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics

|November 13, 2007

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Publisher Correction: Scattering of Sculpted Light in Intact Brain Tissue, with implications for Optogenetics.

Scientific reports·2025

Same author

Deep learning in light-matter interactions.

Nanophotonics (Berlin, Germany)·2024

Same author

Shining Light in Mechanobiology: Optical Tweezers, Scissors, and Beyond.

ACS photonics·2024

Same author

Tired and stressed: direct holographic quasi-static stretching of aging echinocytes and discocytes in plasma using optical tweezers [Invited].

Biomedical optics express·2024

Same author

Roadmap on Deep Learning for Microscopy.

ArXiv·2023

Same author

Far-Field Subwavelength Straight-Line Projection/Imaging by Means of a Novel Double-Near-Zero Index-Based Two-Layer Metamaterial.

Materials (Basel, Switzerland)·2021

Same journal

Tension on dsDNA bound to ssDNA-RecA filaments may play an important role in driving efficient and accurate homology recognition and strand exchange.

Physical review. E, Statistical, nonlinear, and soft matter physics·2016

Same journal

Publisher's Note: Amplitude-phase coupling drives chimera states in globally coupled laser networks [Phys. Rev. E 91, 040901(R) (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016

Same journal

Erratum: Shapes of sedimenting soft elastic capsules in a viscous fluid [Phys. Rev. E 92, 033003 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016

Same journal

Erratum: Attenuation of excitation decay rate due to collective effect [Phys. Rev. E 90, 022142 (2014)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016

Same journal

Publisher's Note: Role of connectivity and fluctuations in the nucleation of calcium waves in cardiac cells [Phys. Rev. E 92, 052715 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016

Same journal

Publisher's Note: Lattice Boltzmann approach for complex nonequilibrium flows [Phys. Rev. E 92, 043308 (2015)].

Physical review. E, Statistical, nonlinear, and soft matter physics·2016

See all related articles

This study presents a novel microviscometer using optical tweezers for precise viscosity measurements of microliter fluid samples. The device accurately measures viscosity across a wide range, even within cellular structures and tears.

Area of Science:

Physics
Biophysics
Materials Science

Background:

Microrheology involves studying fluid viscosity in microscale environments.
Limited sample volumes (microliters) and microscale dimensions present measurement challenges.

Purpose of the Study:

To quantitatively assess the performance and accuracy of a microviscometer utilizing rotating optical tweezers.
To demonstrate the microviscometer's capability for measuring viscosity in challenging biological samples.

Main Methods:

Developed and characterized a microviscometer based on rotating optical tweezers.
Investigated heating effects and dynamic range of viscosity measurements.
Performed in-situ viscosity measurements within cellular membranes and of tear fluid samples.

Related Experiment Videos

Main Results:

The microviscometer demonstrated high accuracy and performance.
Measurements were possible over a dynamic viscosity range of at least two orders of magnitude.
Successfully measured viscosity of intracellular contents and tear fluid.

Conclusions:

The optical tweezers-based microviscometer is a versatile tool for microviscosity measurements.
The device shows significant potential for applications in cell biology and ophthalmology, such as studying tear film dynamics.