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Bioavailability Enhancement: Drug Permeability Enhancement

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices

Parenteral drug delivery systems play a crucial role in modern therapeutics by enabling the direct administration of drugs into the systemic circulation, bypassing the gastrointestinal tract. These systems are particularly valuable for poorly absorbed oral medications that are unstable in the digestive environment or require rapid onset or sustained therapeutic levels. Delivery is achieved through intravenous, intramuscular, or subcutaneous routes, each selected based on the drug's properties...

Ophthalmic Drug Delivery Systems

Ophthalmic Drug Delivery Systems

Ophthalmic drug delivery faces major limitations due to poor absorption across the corneal membrane. This process is primarily driven by diffusion and is influenced by two main factors: the physicochemical properties of the drug and tear drainage. Most ophthalmic drugs, such as pilocarpine, epinephrine, atropine, and local anesthetics, are weak bases. They are typically formulated at an acidic pH to enhance chemical stability. However, this leads to high ionization, reducing their ability to...

Oral Drug Delivery Systems: Delayed-Release Systems

Oral Drug Delivery Systems: Delayed-Release Systems

Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...

Drug Delivery: Overview

Drug Delivery: Overview

The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the gastrointestinal...

Drug Delivery Systems: Different Types

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Conventional oral drug products, termed immediate-release (IR) formulations, are engineered to promptly release their active pharmaceutical ingredient (API) upon ingestion, typically in tablets or capsules. This rapid release often results in swift drug absorption and consequent pharmacodynamic effects, although the timing and intensity can vary depending on the drug's properties. Prodrugs within these formulations require metabolic conversion to activate their pharmacodynamic effects,...

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Related Experiment Video

Updated: Jul 10, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs

Published on: July 27, 2022

Emulsion-based delivery systems for lipophilic bioactive components.

D J McClements¹, E A Decker, J Weiss

¹Dept. of Food Science, Univ. of Massachusetts, Amherst, MA 01003, USA. mcclements@foodsci.umass.edu

Journal of Food Science

|November 13, 2007

Summary

This summary is machine-generated.

Edible delivery systems are crucial for bioactive lipids in food and medicine. Emulsion technologies offer versatile solutions for encapsulating and releasing these compounds using safe ingredients and simple processes.

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Last Updated: Jul 10, 2026

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Published on: July 27, 2022

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier

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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

Published on: August 31, 2019

Area of Science:

Food Science
Materials Science
Biotechnology

Background:

Bioactive lipids like omega-3 fatty acids, carotenoids, and phytosterols require stable edible delivery systems for effective use in food, medical, and pharmaceutical applications.
Current food products face challenges in incorporating these lipids due to instability and degradation.
Edible delivery systems must utilize food-grade ingredients and simple processing methods.

Purpose of the Study:

To review major bioactive lipids needing delivery systems in the food industry.
To highlight challenges in current lipid incorporation into foods.
To overview emulsion-based technologies as potential edible delivery systems.

Main Methods:

Review of existing literature on emulsion-based delivery systems.
Analysis of structures, preparation methods, advantages, limitations, and applications of various systems.
Focus on food-grade ingredients and simple processing operations.

Main Results:

Emulsion technology is well-suited for creating edible delivery systems for bioactive lipids.
Several emulsion-based systems are suitable, including conventional emulsions, multiple emulsions, multilayer emulsions, solid lipid particles, and filled hydrogel particles.
These systems can be produced using GRAS ingredients and common processing techniques.

Conclusions:

Emulsion-based delivery systems offer promising solutions for encapsulating, protecting, and releasing bioactive lipids.
The selection of an appropriate system depends on specific application requirements.
This knowledge facilitates the choice of optimal emulsion-based delivery systems for various industries.