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Subacute hepatic failure due to hepatitis E.

Jeyamani Ramachandran1, Banumathi Ramakrishna, Chundamannil Eapen Eapen

  • 1Departments of GI Sciences, Christian Medical College, Vellore, South India. jeyapati@yahoo.com

Journal of Gastroenterology and Hepatology
|November 13, 2007
PubMed
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Hepatitis E can cause subacute hepatic failure, a condition with a better prognosis than previously thought. Liver biopsy aids diagnosis, and factors like female sex and renal failure indicate poor outcomes.

Area of Science:

  • Hepatology
  • Virology
  • Gastroenterology

Background:

  • Limited data exists on subacute hepatic failure caused by Hepatitis E virus (HEV).
  • HEV is a significant cause of acute liver failure globally.
  • Understanding HEV-induced subacute hepatic failure is crucial for patient management.

Purpose of the Study:

  • To analyze the clinical spectrum of subacute hepatic failure due to HEV.
  • To evaluate the outcomes and prognostic factors in these patients.

Main Methods:

  • Retrospective hospital-based study.
  • Involved patients with acute Hepatitis E and subacute hepatic failure from 2001-2006.
  • Transjugular liver biopsies performed in nine patients.

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Main Results:

  • Twelve patients (4 female, 8 male) were identified.
  • Common symptoms included jaundice and ascites; MELD score was 25.
  • In-hospital mortality was 25%, with 8/9 survivors showing normalized liver function.

Conclusions:

  • HEV-induced subacute hepatic failure is distinct with a better prognosis than other causes.
  • Liver biopsy helps differentiate HEV superinfection from underlying liver disease.
  • Female sex, younger age, encephalopathy, and renal failure are poor prognostic indicators.