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Updated: Jun 27, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
[Theoretical assessment of the effect of galvanic action on nerves]
Abstract:
The nerve state is estimated by a reduced Hodgkin-Huxley model X-X2. When selecting its parameters solutions of equations of Fokker-Planck and Poisson type are used. They model ion diffusion in the electric field under galvanic effect when an electrode is located near the nerve. By the method of phase pattern there are studied the system stationary state, condition of electroneutrality and possibility of achieving autooscillation regime of the nerve excitation varying galvanic stimulation parameters, as well as of ionic composition of the medium which surrounds the nerve.
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