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Related Experiment Video

Updated: Jul 10, 2026

Application of Bedside Lower Extremity Rehabilitation Robots in Stroke Rehabilitation: A Randomized Controlled Trial
04:38

Application of Bedside Lower Extremity Rehabilitation Robots in Stroke Rehabilitation: A Randomized Controlled Trial

Published on: November 28, 2025

Protocol for the Locomotor Experience Applied Post-stroke (LEAPS) trial: a randomized controlled trial.

Pamela W Duncan1, Katherine J Sullivan, Andrea L Behrman

  • 1Division of Doctor of Physical Therapy, Department of Community and Family Medicine, Duke University, Durham, North Carolina, USA. Pamela.Duncan@Duke.edu

BMC Neurology
|November 13, 2007
PubMed
Summary

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This study investigates if specialized locomotor training (LTP) improves walking recovery in stroke survivors compared to a home exercise program (HEP). It assesses the effectiveness of early versus late LTP timing on gait speed and recovery outcomes.

Area of Science:

  • Neurorehabilitation
  • Clinical Trials
  • Stroke Recovery

Background:

  • Locomotor training (LTP) using body weight support and treadmills is increasingly used for post-stroke rehabilitation.
  • A well-designed trial is needed to establish the effectiveness of this intervention.
  • The Locomotor Experience Applied Post-Stroke (LEAPS) trial addresses this need.

Purpose of the Study:

  • To determine if specialized LTP improves walking recovery at one year post-stroke compared to a home exercise program (HEP).
  • To assess if the timing of LTP (early vs. late) impacts gait speed at one year.
  • To investigate if initial impairment severity influences LTP effectiveness.

Main Methods:

  • 400 adults with moderate to severe walking limitations within 30 days post-stroke were recruited.

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A Rehabilitation Program of Exoskeleton-assisted Body Weight-Supported Treadmill Training with Non-immersive Virtual Reality for Stroke Patients

Published on: May 16, 2025

Related Experiment Videos

Last Updated: Jul 10, 2026

Application of Bedside Lower Extremity Rehabilitation Robots in Stroke Rehabilitation: A Randomized Controlled Trial
04:38

Application of Bedside Lower Extremity Rehabilitation Robots in Stroke Rehabilitation: A Randomized Controlled Trial

Published on: November 28, 2025

A Rehabilitation Program of Exoskeleton-assisted Body Weight-Supported Treadmill Training with Non-immersive Virtual Reality for Stroke Patients
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A Rehabilitation Program of Exoskeleton-assisted Body Weight-Supported Treadmill Training with Non-immersive Virtual Reality for Stroke Patients

Published on: May 16, 2025

  • Participants were stratified by impairment severity and randomized to early LTP, late LTP, or early HEP.
  • Interventions (LTP and HEP) consisted of 36 sessions over 12 weeks; primary outcomes included achieving specific gait speeds.

    • Main Results:

    • The study is powered to detect a 20% difference in successful walking recovery between LTP and HEP groups.
    • It can also detect a 0.1 m/s mean difference in gait speed change between the two LTP groups.
    • The effect of the number of treatment sessions on gait speed changes will be analyzed.

    Conclusions:

    • This phase III randomized clinical trial aims to provide evidence for optimizing post-stroke walking recovery programs.
    • The findings will guide clinical practice regarding the use and timing of locomotor training.