Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Hemodialysis I: Introduction

Hemodialysis I: Introduction

Hemodialysis (HD) is a medical treatment that artificially removes waste products, excess fluids, and toxins from the blood when the kidneys are no longer able to perform these functions effectively. In this process, blood is filtered through a semipermeable membrane, allowing for the selective removal of waste while preserving necessary components like blood cells and proteins. Hemodialysis is typically performed in patients with end-stage renal disease (ESRD) or severe kidney...

Dialysis

Dialysis

Dialysis is a diffusion-based purification process that separates analyte molecules from a complex matrix. This is accomplished by allowing molecules in the solution to pass through a semipermeable membrane into a liquid on the other side. The membrane is usually made of cellulose acetate or cellulose nitrate, and the second liquid must be miscible with the solution. Ions (e.g., chloride or sodium) or organic molecules (e.g., glucose) can pass through the membrane pores, which generally have...

Dialysis

Dialysis

Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...

Hemodialysis II: Procedure and Complications

Hemodialysis II: Procedure and Complications

DialyzersA hemodialysis (HD) dialyzer is a plastic cartridge containing thousands of parallel hollow fibers, which serve as semipermeable membranes. These fibers are typically made from cellulose-based or other synthetic materials. During HD, blood is pumped into the top of the cartridge and distributed among these fibers. Simultaneously, dialysis fluid, known as dialysate, is introduced into the bottom of the cartridge, bathing the outside of the fibers. Across the semipermeable membrane,...

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Extracorporeal Removal of Drugs: Hemoperfusion and Hemofiltration

Hemoperfusion and hemofiltration are critical techniques in medical treatments to eliminate accumulated drugs, metabolites, and electrolytes from the bloodstream. These methods are particularly vital in cases of accidental poisoning and drug overdose.Hemoperfusion involves passing blood through an adsorbent material to remove unwanted substances. The main adsorbents used in hemoperfusion include activated charcoal and Amberlite resins. Activated charcoal can adsorb both polar and nonpolar...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Freedom in retirement home, facing confinement].

Ethique & sante·2020

Same author

Improved Detection of preclinical Colorectal Liver Metastases by High Resolution Ultrasound including Molecular Ultrasound Imaging using the targeted Contrast Agent BR55.

Ultraschall in der Medizin (Stuttgart, Germany : 1980)·2016

Same author

Efficacy of a therapeutic treatment using gas-filled microbubble-associated phospholipase A2 in a mouse model of honeybee venom allergy.

Allergy·2016

Same author

Prophylactic immunization of mice with phospholipase A2-loaded gas-filled microbubbles is protective against Th2-mediated honeybee venom allergy.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology·2015

Same author

Sonothrombolysis: the contribution of stable and inertial cavitation to clot lysis.

Ultrasound in medicine & biology·2015

Same author

Ultrasound contrast agents for ultrasound molecular imaging.

Zeitschrift fur Gastroenterologie·2014

Search research articles

Related Experiment Video

Updated: Jul 10, 2026

Studying Cavitation Enhanced Therapy

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

Acoustical bubble trapper applied to hemodialysis.

P Palanchon¹, B Birmelé, F Tranquart

¹INSERMU619, CHU Bretonneau, Tours, France. palanchon@med.univ-tours.fr

Ultrasound in Medicine & Biology

|November 13, 2007

Summary

This study developed an ultrasound bubble trapper to remove gaseous microemboli from dialysis lines. The device successfully reduced microembolic signals by up to 70%, enhancing patient safety during hemodialysis.

More Related Videos

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Published on: May 9, 2021

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Published on: June 12, 2011

Related Experiment Videos

Last Updated: Jul 10, 2026

Studying Cavitation Enhanced Therapy

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Induction of Microstreaming by Nonspherical Bubble Oscillations in an Acoustic Levitation System

Published on: May 9, 2021

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Introduction to the Ultrasound Targeted Microbubble Destruction Technique

Published on: June 12, 2011

Area of Science:

Biomedical Engineering
Medical Devices
Fluid Dynamics

Background:

Gaseous microemboli in extracorporeal circuits, like dialysis machines, pose risks.
These air bubbles can cause severe pulmonary complications in hemodialysis patients.

Purpose of the Study:

To develop and evaluate an ultrasound-based system for trapping gaseous microemboli.
To prevent air bubbles from reaching patients during hemodialysis.

Main Methods:

A laboratory-developed bubble trapper used ultrasound waves (500 kHz, 500 kPa) to redirect microemboli.
The device directed bubbles into a subchannel using acoustic radiation force.
Doppler probes monitored microembolic signals (MES) at varying flow rates (200-500 mL/min).

Main Results:

Without ultrasound, MES counts before and after the trapper were similar (5-150 MES/min).
Activating the ultrasound trapper reduced MES by up to 70%.
Bubbles were fragmented or trapped in the subchannel.

Conclusions:

An ultrasound-based bubble trapper effectively removes gaseous microemboli from extracorporeal lines.
This simple system shows promise for improving hemodialysis safety.
The technology can filter air microemboli in medical tubing systems.