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Updated: Jul 21, 2026

Generation of Lymph Node-fat Pad Chimeras for the Study of Lymph Node Stromal Cell Origin
Published on: December 16, 2013
Molecular interactions between stromal cells and B lymphocyte precursors
1Oklahoma Medical Research Foundation, Oklahoma City 73104.
Abstract:
Long term culture techniques, cloned stromal lines, recombinant cytokines and monoclonal antibodies have provided powerful experimental tools for studying bone marrow functions. Rapid progress has been made in characterizing large reticular stromal cells in bone marrow that provide a nurturing microenvironment for B lymphocyte precursors. It is now clear that they have differentiation potential, that they can respond to inflammatory episodes and that they can make at least 12 regulatory cytokines. Pairs of cell adhesion molecules have also been defined which participate in B lymphopoiesis. These include CD44, hyaluronate, VLA-4 and a VCAM-like protein.
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