Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Functional Brain Systems: Limbic System01:15

Functional Brain Systems: Limbic System

The limbic system, often called the "emotional brain," is a complex set of structures located deep within the brain. The intricate network of the limbic system supports a wide range of psychological functions, from emotional regulation to memory formation and sensory processing. This functional brain region encompasses specific parts of the diencephalon and the cerebrum, integrating the higher mental functions of the cerebral cortex with the primitive emotional responses of the deep brain...
Role of Amygdala in Memory01:16

Role of Amygdala in Memory

The amygdala is a small, almond-shaped structure responsible for processing and storing memories, particularly those linked to emotions like fear and stress. It plays an essential role in the brain's response to emotionally significant events and often enhances memory formation by triggering stress hormone release. The amygdala is vital for encoding and retrieving memories associated with fear or stress, a process that is adaptive by helping organisms avoid dangerous situations.
One of the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Wherefore art thou competitors? How situational affordances help differentiate among prosociality, individualism, and competition.

European journal of personality·2026
Same author

Contributions of insula and superior temporal sulcus to interpersonal guilt and responsibility in social decisions.

eLife·2026
Same author

Changes in Gray Matter Morphology and White Matter Microstructure Across the Adult Lifespan in People With Temporal Lobe Epilepsy.

Neurology·2025
Same author

Social influence effects on food valuation generalize based on conceptual similarity.

Appetite·2025
Same author

Does a single dose of testosterone increase willingness to compete, confidence, and risk-taking in men? Evidence from two randomised placebo-controlled experiments.

Hormones and behavior·2024
Same author

A structural MRI marker predicts individual differences in impulsivity and classifies patients with behavioral-variant frontotemporal dementia from matched controls.

bioRxiv : the preprint server for biology·2024

Related Experiment Video

Updated: Jul 10, 2026

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
09:00

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

Amygdala tractography predicts functional connectivity and learning during feedback-guided decision-making.

Michael X Cohen1, Christian E Elger, Bernd Weber

  • 1Department of Epileptology, University of Bonn, Germany. mcohen@ucdavis.edu

Neuroimage
|November 13, 2007
PubMed
Summary

Brain connectivity, including the amygdala, is crucial for flexible behavior. This study reveals how anatomical and functional connections in the amygdala circuit support learning from feedback and adapting to changing rules.

More Related Videos

How to Detect Amygdala Activity with Magnetoencephalography using Source Imaging
10:48

How to Detect Amygdala Activity with Magnetoencephalography using Source Imaging

Published on: June 3, 2013

Functional Imaging with Reinforcement, Eyetracking, and Physiological Monitoring
08:47

Functional Imaging with Reinforcement, Eyetracking, and Physiological Monitoring

Published on: November 13, 2008

Related Experiment Videos

Last Updated: Jul 10, 2026

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex
09:00

Investigating the Function of Deep Cortical and Subcortical Structures Using Stereotactic Electroencephalography: Lessons from the Anterior Cingulate Cortex

Published on: April 15, 2015

How to Detect Amygdala Activity with Magnetoencephalography using Source Imaging
10:48

How to Detect Amygdala Activity with Magnetoencephalography using Source Imaging

Published on: June 3, 2013

Functional Imaging with Reinforcement, Eyetracking, and Physiological Monitoring
08:47

Functional Imaging with Reinforcement, Eyetracking, and Physiological Monitoring

Published on: November 13, 2008

Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Flexible behavior in dynamic environments depends on fronto-limbic networks, involving the amygdala, orbitofrontal cortex, and striatum.
  • Animal studies highlight the importance of inter-regional interactions for feedback-guided learning, but human mechanisms remain unclear.

Purpose of the Study:

  • To investigate the role of anatomical and functional brain connectivity in human feedback-guided learning and goal-directed behavior.
  • To elucidate how amygdala-related circuits mediate adaptive responses to feedback and rule changes.

Main Methods:

  • Utilized diffusion-weighted imaging (DWI) for structural connectivity (white matter tract analysis) and functional MRI (fMRI) for functional connectivity.
  • Employed a feedback-guided reversal learning task to assess behavioral adaptation.
  • Analyzed connectivity between the amygdala and regions like the hippocampus, orbitofrontal cortex, and ventral striatum.

Main Results:

  • The strength of white matter tracts from the amygdala to the hippocampus, orbitofrontal cortex, and ventral striatum predicted behavioral adaptation to feedback.
  • Amygdala functional connectivity with these regions also correlated with behavioral adaptation.
  • A dissociation was found: amygdala-hippocampus connectivity predicted response switching, while amygdala-orbitofrontal cortex connectivity predicted learning after rule reversals.

Conclusions:

  • Provides novel insights into the interplay of anatomy and function in amygdala-related circuits for feedback-guided learning.
  • Demonstrates distinct roles for amygdala-hippocampus and amygdala-orbitofrontal cortex circuits in different aspects of adaptive behavior.