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Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
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Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations

Published on: October 20, 2017

Inflammatory molecule expression in cerebral arteriovenous malformations

Kingsley P Storer1, Jian Tu, Athula Karunanayaka

  • 1Prince of Wales Medical Research Institute, University of New South Wales, Sydney, New South Wales, Australia.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
|November 13, 2007
PubMed

Insights

Cerebral arteriovenous malformations (AVMs) show increased inflammatory molecules like E-selectin and VCAM-1 compared to normal vessels. These changes may impact AVM response to treatments like radiosurgery and embolization.

Area of Science:

  • Neuroscience
  • Vascular Biology
  • Immunology

Background:

  • Cerebral arteriovenous malformations (AVMs) are complex vascular lesions.
  • The role of inflammation in AVM pathophysiology and treatment response is not fully understood.

Purpose of the Study:

  • To compare the expression of specific inflammatory molecules in AVMs versus normal cerebral vessels.
  • To investigate the influence of pre-operative embolization on inflammatory molecule expression in AVMs.

Main Methods:

  • Immunohistochemistry was used to examine inflammatory markers in 15 AVM surgical specimens and 3 control specimens.
  • Evaluated markers included P- and E-selectin, ICAM-1, VCAM-1, PECAM-1, and von Willebrand factor.

Main Results:

  • AVMs demonstrated significant upregulation of E-selectin, VCAM-1, and ICAM-1 compared to normal cerebral vasculature.
  • Pre-operative embolization correlated with increased expression of E-selectin and VCAM-1 in AVMs.

Conclusions:

  • The endothelium of AVMs exhibits distinct molecular properties compared to normal cerebral vessels.
  • Inflammatory molecules are likely biologically relevant in the response of AVMs to radiosurgery and embolization.

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