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Updated: Jul 10, 2026
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Comprehensive Endovascular and Open Surgical Management of Cerebral Arteriovenous Malformations
Published on: October 20, 2017
Inflammatory molecule expression in cerebral arteriovenous malformations.
Kingsley P Storer1, Jian Tu, Athula Karunanayaka
1Prince of Wales Medical Research Institute, University of New South Wales, Sydney, New South Wales, Australia.
Summary
Cerebral arteriovenous malformations (AVMs) show increased inflammatory molecules like E-selectin and VCAM-1 compared to normal vessels. These changes may impact AVM response to treatments like radiosurgery and embolization.
Area of Science:
- Neuroscience
- Vascular Biology
- Immunology
Background:
- Cerebral arteriovenous malformations (AVMs) are complex vascular lesions.
- The role of inflammation in AVM pathophysiology and treatment response is not fully understood.
Purpose of the Study:
- To compare the expression of specific inflammatory molecules in AVMs versus normal cerebral vessels.
- To investigate the influence of pre-operative embolization on inflammatory molecule expression in AVMs.
Main Methods:
- Immunohistochemistry was used to examine inflammatory markers in 15 AVM surgical specimens and 3 control specimens.
- Evaluated markers included P- and E-selectin, ICAM-1, VCAM-1, PECAM-1, and von Willebrand factor.
Main Results:
- AVMs demonstrated significant upregulation of E-selectin, VCAM-1, and ICAM-1 compared to normal cerebral vasculature.
- Pre-operative embolization correlated with increased expression of E-selectin and VCAM-1 in AVMs.
Conclusions:
- The endothelium of AVMs exhibits distinct molecular properties compared to normal cerebral vessels.
- Inflammatory molecules are likely biologically relevant in the response of AVMs to radiosurgery and embolization.
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