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Related Experiment Videos

Poststeroid panniculitis.

Eun Ji Kwon1, Patrick O Emanuel, Canin H Gribetz

  • 1Department of Dermatology, Case Western Reserve University, Cleveland, OH, USA.

Journal of Cutaneous Pathology
|December 6, 2007
PubMed
Summary
This summary is machine-generated.

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Poststeroid panniculitis (PSP) is a rare skin reaction in children after stopping steroids, causing red bumps on the cheeks. Diagnosis relies on history and characteristic biopsy findings of inflammation and needle-shaped clefts.

Area of Science:

  • Dermatology
  • Pediatrics
  • Pathology

Background:

  • Poststeroid panniculitis (PSP) is an uncommon adverse effect of systemic corticosteroid treatment.
  • It typically manifests in children following rapid reduction or discontinuation of steroid therapy.

Observation:

  • Clinical presentation includes erythematous nodules and indurated plaques on the cheeks.
  • Symptoms appear within days to weeks after steroid tapering or cessation.
  • The differential diagnosis for childhood cheek erythema is extensive.

Findings:

  • Histopathological examination reveals lobular panniculitis with mixed inflammatory infiltrates, notably lacking vasculitis.
  • Characteristic findings include needle-shaped clefts within adipocytes, a distinctive feature.

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  • The histological differential diagnosis for adipocytes with needle-shaped crystals is narrow.

    • Implications:

    • Accurate diagnosis of PSP is crucial for appropriate patient management.
    • Understanding the clinicopathological features aids in differentiating PSP from other conditions.
    • This case highlights the importance of considering PSP in children with cheek lesions after steroid therapy.