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Hypoxia and the unfolded protein response

Constantinos Koumenis1, Meixia Bi, Jiangbin Ye

  • 1Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA.

Methods in Enzymology
|November 14, 2007
PubMed
Summary

Tumor hypoxia, a state of low oxygen in tumors, promotes aggressive cancer growth and metastasis. Understanding these cellular and molecular changes is key to developing effective cancer treatments.

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