Exercise responses in boys with attention deficit/hyperactivity disorder: effects of stimulant medication
Anthony D Mahon1, Brooke R Stephens, Andrew S Cole
1Human Performance Laboratory, Ball State University, Muncie, Indiana 47306, USA. tmahon@bsu.edu
Objective:
The effect of stimulant medication on exercise responses was studied in 14 boys (10.9 +/- 1.1 years) with attention deficit/hyperactivity disorder (ADHD).
Method:
Exercise, with and without medication, was performed at 25 W, 50 W, and 75 W, followed by a peak exercise test.
Result:
Submaximal heart rate (HR) was significantly higher by ~8 to 13 b.min(-1) across the three intensities during the medication trial, but oxygen uptake (VO(2)), respiratory exchange ratio (RER), and perceived exertion were similar (p > .05). At peak exercise, VO(2), HR, and work rate were attenuated (p < or = .05) in the absence of medication but not RER or perceived exertion. The decreased peak exercise responses were apparent in 6 of 13 participants.
Conclusion:
Stimulant medication raises submaximal HR but does not affect other cardiorespiratory measures or perceived exertion. Without medication physiological responses at peak exercise are attenuated in some but not all boys with ADHD.
More Related Videos
Related Concept Videos
Attention-Deficit/Hyperactivity Disorder
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Stimulants
Cocaine can be administered via snorting, injection, or smoking. It primarily functions by blocking the reuptake of dopamine, resulting in a euphoric high characterized by an intense sensation of happiness and...
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating sympathetic or...
Adrenergic Agonists: Mixed-Action Agents
Ephedrine and pseudoephedrine lack a catecholamine group, making them less susceptible to degradation by metabolic enzymes. They have increased oral bioavailability and lipophilicity, resulting in a longer duration of action. Their response is reduced by...
Adrenergic Agonists: Therapeutic Uses
Emergency and Intensive Care Unit (ICU) applications: Pressor agents increase blood pressure, heart rate, and contractility in shock and organ failure situations. Dopamine can induce vasodilation and stimulate adrenoceptors. Endogenous catecholamines are effective in treating cardiogenic shock. α2-agonists like clonidine can reverse anesthesia-induced hypertension.
Allergies and anaphylaxis:...
CNS Stimulants: Cocaine, Amphetamines and Cannabinoids


