Jove
Visualize
Contact Us

Related Concept Videos

Biological Effects of Radiation02:59

Biological Effects of Radiation

All radioactive nuclides emit high-energy particles or electromagnetic waves. When this radiation encounters living cells, it can cause heating, break chemical bonds, or ionize molecules. The most serious biological damage results when these radioactive emissions fragment or ionize molecules. For example, α and β particles emitted from nuclear decay reactions possess much higher energies than ordinary chemical bond energies. When these particles strike and penetrate matter, they produce ions...
Absorption of Radiation01:05

Absorption of Radiation

The rate of heat transfer by emitted radiation is described by the Stefan-Boltzmann law of radiation:
Radiation: Applications01:17

Radiation: Applications

The average temperature of Earth is the subject of much current discussion. Earth is in radiative contact with both the Sun and dark space; it receives almost all its energy from the radiation of the Sun and reflects some of it into outer space. Dark space is very cold, about 3 K, so Earth radiates energy into it. For instance, heat transfer occurs from soil and grasses, the rate of which can be so rapid that frost can occur on clear summer evenings, even in warm latitudes.
The average...
Mutations01:35

Mutations

Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A circular economy framework to mitigate water scarcity and river pollution in Delhi, India.

Scientific reports·2026
Same author

Chemomodulatory Potential of Flaxseed Oil Against DMBA/Croton Oil-Induced Skin Carcinogenesis in Mice.

Integrative cancer therapies·2015
Same author

Mutational analysis of telomere complex genes in Indian population with acquired aplastic anemia.

Leukemia research·2015
Same author

A rare case of small bowel obstruction due to primary trichobezoar.

Journal of clinical and diagnostic research : JCDR·2014
Same author

Prophylactic Role of Averrhoa carambola (Star Fruit) Extract against Chemically Induced Hepatocellular Carcinoma in Swiss Albino Mice.

Advances in pharmacological sciences·2014
Same author

Evidences for the Involvement of Monoaminergic and GABAergic Systems in Antidepressant-like Activity of Tinospora cordifolia in Mice.

Indian journal of pharmaceutical sciences·2011
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jul 10, 2026

Dosimetry for Cell Irradiation using Orthovoltage (40-300 kV) X-Ray Facilities
06:51

Dosimetry for Cell Irradiation using Orthovoltage (40-300 kV) X-Ray Facilities

Published on: February 20, 2021

Karyoanomalic frequency during radiation therapy.

Rimpu Kumari1, Arun Chaugule, P K Goyal

  • 1Radiation and Cancer Biology Laboratory, Department of Zoology, University of Rajasthan, India.

Journal of Cancer Research and Therapeutics
|November 14, 2007
PubMed
Summary

Serial cytology during radiotherapy revealed that increased nuclear abnormalities correlate with higher radiation doses in head and neck cancers. The micronucleus assay effectively assesses radiation-induced biological damage, aiding in the identification of tumor radiosensitivity.

More Related Videos

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields (TTFields)
08:14

Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields (TTFields)

Published on: May 4, 2017

Related Experiment Videos

Last Updated: Jul 10, 2026

Dosimetry for Cell Irradiation using Orthovoltage (40-300 kV) X-Ray Facilities
06:51

Dosimetry for Cell Irradiation using Orthovoltage (40-300 kV) X-Ray Facilities

Published on: February 20, 2021

Stereotactic Radiosurgery for Gynecologic Cancer
10:35

Stereotactic Radiosurgery for Gynecologic Cancer

Published on: April 17, 2012

Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields (TTFields)
08:14

Determining the Optimal Inhibitory Frequency for Cancerous Cells Using Tumor Treating Fields (TTFields)

Published on: May 4, 2017

Area of Science:

  • Oncology
  • Radiotherapy
  • Cytopathology

Background:

  • Head and neck cancers present a significant clinical challenge.
  • Fractionated radiotherapy is a cornerstone treatment modality.
  • Assessing tumor radiosensitivity is crucial for treatment optimization.

Purpose of the Study:

  • To investigate the relationship between oral cancer radiosensitivity and nuclear abnormalities.
  • To evaluate the dose-dependent correlation of nuclear abnormalities during fractionated radiotherapy.

Main Methods:

  • 30 squamous cell carcinoma patients undergoing radiotherapy were studied.
  • Serial cytological smears were analyzed for micronucleated, binucleated, and multinucleated cells.
  • Cellular abnormalities were quantified per 1000 uninucleated cells at varying radiation doses (0-24 Gy).

Main Results:

  • A statistically significant increase in nuclear abnormalities (micronucleated, binucleated, multinucleated cells) was observed with escalating radiation doses.
  • Pre-treatment values for these abnormalities were 3.5, 10.1, and 4.2, respectively.
  • At 24 Gy, the mean values increased to 12.8, 18.5, and 15.1, with p < 0.0001.

Conclusions:

  • The micronucleus assay is a valuable tool for assessing radiation-induced biological damage.
  • This assay can aid in identifying tumor radiosensitivity in head and neck cancers.
  • Cytological analysis of nuclear abnormalities provides insights into treatment response during radiotherapy.