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09:02
Immunoglobulin Gene Sequence Analysis In Chronic Lymphocytic Leukemia: From Patient Material To Sequence Interpretation
Published on: November 26, 2018
Paraneoplastic leukocytoclastic vasculitis in chronic lymphoid leukemia
B S Yadav1, S C Sharma, R K Kapoor
1Department of Radiotherapy, PGIMER, Chandigarh, India. drbudhi@gmail.com
Journal of Cancer Research and Therapeutics
|November 14, 2007
Summary
A patient with chronic lymphoid leukemia (CLL) developed a severe skin rash. Treatment with leukeran and glucocorticoids successfully resolved the vasculitis symptoms.
Area of Science:
- Dermatology
- Hematology
- Oncology
Background:
- Chronic lymphoid leukemia (CLL) is a hematologic malignancy.
- Cutaneous manifestations can occur in patients with CLL.
- Leukocytoclastic vasculitis is an inflammatory condition affecting small blood vessels.
Observation:
- A 50-year-old female with known CLL presented with widespread ecchymoses, purpuric spots, papules, and nodules.
- The skin lesions were associated with severe burning and itching, and an exacerbation of CLL.
- Lesions were most prominent on the lower limbs and face.
Findings:
- Skin biopsy confirmed leukocytoclastic vasculitis.
- The patient's skin lesions showed significant regression following treatment.
- Treatment involved leukeran and glucocorticoids.
Implications:
- This case highlights a rare cutaneous manifestation of CLL.
- Early diagnosis and appropriate treatment of leukocytoclastic vasculitis are crucial in CLL patients.
- Management requires a multidisciplinary approach involving hematology and dermatology.
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