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Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone

Published on: September 9, 2020

Post-irradiation angiosarcoma of bone.

Srabani Mittal¹, Chanchal Goswami, Nandini Kanoria

¹Department of Medical Oncology, B P Poddar Hospital and Medical Research Ltd, Kolkata, India. rinkumittal@rediffmail.com

Journal of Cancer Research and Therapeutics

|November 14, 2007

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This case report details a rare instance of epithelioid angiosarcoma developing ten years after radiation therapy for a giant cell tumor. The patient successfully managed recurrence with surgery and chemotherapy.

Area of Science:

Orthopedic Oncology
Radiation Oncology
Pathology

Background:

Radiation therapy is a cornerstone in malignancy treatment.
Post-radiation sarcomas are rare, particularly angiosarcomas in irradiated bone.
Giant cell tumors are benign bone neoplasms often treated with radiation.

Observation:

A 67-year-old male developed a high-grade epithelioid angiosarcoma in the right humerus ten years post-irradiation for a giant cell tumor.
Initial presentation included a painful shoulder swelling with radiographic evidence of cortical erosion and lytic lesions.
Histopathological diagnosis was challenging, ultimately confirming post-radiation angiosarcoma.

Findings:

The patient underwent surgical excision, hemiarthroplasty, and bone grafting.

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Recurrence was observed one year post-initial surgery, necessitating wide resection and prosthesis replacement.

Adjuvant chemotherapy with doxorubicin and ifosfamide was administered.

Implications:

This case highlights the uncommon but significant risk of secondary angiosarcoma following radiation therapy.
Early recognition and aggressive multimodal treatment are crucial for managing post-radiation sarcomas.
Further research into the long-term oncological risks of radiation therapy is warranted.