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Low serum testosterone concentration in middle-aged men with type 2 diabetes
Michiaki Fukui1, Jintetsu Soh, Muhei Tanaka
1Department of Endocrinology and Metabolism, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Endocrine Journal
|November 14, 2007
Summary
Men with type 2 diabetes have lower testosterone levels than healthy men across all adult age groups. This study confirms lower androgen concentrations in diabetic men, highlighting a potential link to cardiovascular health.
Area of Science:
- Endocrinology
- Metabolic Syndrome
- Andrology
Background:
- Low endogenous androgens are associated with insulin resistance and atherosclerosis.
- Diabetic men may have lower serum testosterone, but large-scale studies are lacking.
Purpose of the Study:
- To investigate if endogenous androgen concentration is lower in Japanese men with type 2 diabetes compared to healthy men.
- To identify factors associated with low serum testosterone in type 2 diabetes patients.
Main Methods:
- Serum free testosterone was measured in 524 healthy men and 331 Japanese men with type 2 diabetes (aged 40-69).
- Relationships between free testosterone, luteinizing hormone (LH), and cardiovascular risk factors (age, blood pressure, lipids, HbA1c, BMI) were analyzed.
Main Results:
- Serum free testosterone was significantly lower in type 2 diabetes patients compared to healthy men across all age groups (40-49, 50-59, 60-69).
- A negative correlation was observed between serum free testosterone and LH concentrations (r = -0.326, P<0.0001).
Conclusions:
- Serum free testosterone concentration is significantly lower in Japanese men with type 2 diabetes compared to healthy men across decades of adult life.
- These findings support a link between type 2 diabetes and reduced androgen levels in men.
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