Related Experiment Video
Updated: Jul 10, 2026
08:27
A New Hybrid Quantitative Evaluation Model for Axillary Junctional Hemorrhage in Swine
Published on: December 6, 2024
Is survival time after hemorrhage a heritable, quantitative trait?: an initial assessment
Harold G Klemcke1, David G Baer, V Shane Pankratz
1US Army Institute of Surgical Research, 3400 Rawley E. Chambers Avenue, Fort Sam Houston, TX 78234, USA. harold.klemcke@amedd.army.mil
Shock (Augusta, Ga.)
|November 14, 2007
Summary
Genetic factors significantly influence survival rates following hemorrhage. This study identified distinct survival times among inbred rat strains, suggesting a heritable component to hemorrhage resilience.
Area of Science:
- Trauma Research
- Genetics
- Physiology
Background:
- Hemorrhage survival is critical for trauma patients.
- Previous studies indicate variability in hemorrhage outcomes.
- Genetic influences on hemorrhage survival are not fully understood.
Purpose of the Study:
- To investigate the genetic basis of differential survival to hemorrhage.
- To identify inbred rat strains with divergent survival times after blood loss.
Main Methods:
- Controlled hemorrhage was induced in 15 inbred rat strains.
- Survival time was measured for up to 6 hours post-hemorrhage.
- Statistical analysis estimated heritability of survival.
Main Results:
- Significant variation in survival times (up to 7.7-fold difference) was observed among rat strains.
- Heritability of hemorrhage survival was estimated at approximately 48%.
- Specific strains like Brown Norway and DA exhibited notably long and short survival, respectively.
Conclusions:
- Inbred rat strains display genetically influenced, divergent survival responses to hemorrhage.
- These findings suggest multiple genetic factors contribute to hemorrhage resilience.
- Divergent strains offer a valuable model for future genetic research into hemorrhage survival mechanisms.
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