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Updated: Jul 10, 2026

Paw-Print Analysis of Contrast-Enhanced Recordings (PrAnCER): A Low-Cost, Open-Access Automated Gait Analysis System for Assessing Motor Deficits
Published on: August 12, 2019
Anticholinergic-responsive gait freezing in a patient with pantothenate kinase-associated neurodegeneration
Chul Hyoung Lyoo1, Holger Prokisch, Thomas Meitinger
1Department of Neurology, Youngdong Severance Hospital, Yonsei University College of Medicine, Seoul, South Korea.
Abstract:
A 43-year-old male patient suddenly developed freezing of gait (FOG) when making a first step, turning, or passing through a narrow path. Dystonic plantar flexion of his left foot always accompanied with FOG. He could walk without FOG when stepping on visual cues. Brain magnetic resonance imaging study showed typical "eye of the tiger" sign in the globus pallidus. He had heterozygous mutations in the exons 3 and 4 in the PANK2 gene. His FOG dramatically responded to the anticholinergic treatment. We report the first instance of a patient with genetically confirmed pantothenate kinase associated neurodegeneration showing typical FOG that responded to anticholinergic treatment.
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