Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription factors...
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
Overview of Skeletal Muscle01:15

Overview of Skeletal Muscle

Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

An enzyme kinetic model for quantitative interpretation of the role of nicotinamide nucleotide transhydrogenase (NNT) in cell physiology.

Free radical biology & medicine·2026
Same author

Cranial neural crest cells in zebrafish: Insights into craniofacial skeletal development and malformation.

Bone·2026
Same author

Impact of three types of presurgical infant orthopedics on nasolabial appearance in unilateral cleft lip and palate: a 4-year follow-up study.

The Angle orthodontist·2026
Same author

Effects of Nintedanib on Orofacial Fibroblasts and Myoblasts.

Biomolecules·2026
Same author

Progression of peripheral blood mononuclear cell mitochondrial function during the early phase of sepsis in intensive care unit patients.

Scientific reports·2026
Same author

Assessing the involvement of tumor-secreted factors in the inhibition of muscle differentiation.

Biochimica et biophysica acta. Molecular cell research·2025

Related Experiment Video

Updated: Jul 10, 2026

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection
07:39

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection

Published on: January 1, 2017

Skeletal muscle development and regeneration.

Sander Grefte1, Anne Marie Kuijpers-Jagtman, Ruurd Torensma

  • 1Department of Orthodontics and Oral Biology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands.

Stem Cells and Development
|November 15, 2007
PubMed
Summary

Satellite cells are crucial for muscle regeneration and repair. Therapies targeting these stem cells and using scaffolds aim to improve muscle healing and prevent scarring.

More Related Videos

Analyzing Satellite Cell Function During Skeletal Muscle Regeneration by Cardiotoxin Injury and Injection of Self-delivering siRNA In Vivo
06:37

Analyzing Satellite Cell Function During Skeletal Muscle Regeneration by Cardiotoxin Injury and Injection of Self-delivering siRNA In Vivo

Published on: September 18, 2019

Applications of In Vivo Functional Testing of the Rat Tibialis Anterior for Evaluating Tissue Engineered Skeletal Muscle Repair
07:13

Applications of In Vivo Functional Testing of the Rat Tibialis Anterior for Evaluating Tissue Engineered Skeletal Muscle Repair

Published on: October 7, 2016

Related Experiment Videos

Last Updated: Jul 10, 2026

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection
07:39

Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection

Published on: January 1, 2017

Analyzing Satellite Cell Function During Skeletal Muscle Regeneration by Cardiotoxin Injury and Injection of Self-delivering siRNA In Vivo
06:37

Analyzing Satellite Cell Function During Skeletal Muscle Regeneration by Cardiotoxin Injury and Injection of Self-delivering siRNA In Vivo

Published on: September 18, 2019

Applications of In Vivo Functional Testing of the Rat Tibialis Anterior for Evaluating Tissue Engineered Skeletal Muscle Repair
07:13

Applications of In Vivo Functional Testing of the Rat Tibialis Anterior for Evaluating Tissue Engineered Skeletal Muscle Repair

Published on: October 7, 2016

Area of Science:

  • Muscle biology
  • Regenerative medicine

Background:

  • Satellite cells are stem cells essential for postnatal muscle growth and regeneration.
  • Muscle injury healing is often impaired by scar tissue formation, hindering functional recovery.
  • Identifying factors to enhance muscle healing and reduce scarring is a significant research goal.

Purpose of the Study:

  • To explore the role of satellite cells in muscle repair.
  • To review current and emerging therapeutic strategies for muscle injury.
  • To highlight the potential of cell-based and scaffold-based approaches in regenerative medicine.

Main Methods:

  • Review of scientific literature on satellite cell biology and muscle regeneration.
  • Analysis of growth factor-based and cell-based therapeutic strategies.
  • Examination of scaffold applications in tissue engineering for muscle repair.

Main Results:

  • Satellite cells possess self-renewal capabilities, making them central to muscle healing therapies.
  • Growth factor and satellite cell therapies are being developed for minor injuries.
  • Scaffolds, with or without cells, are crucial for major tissue loss and in vitro muscle generation.

Conclusions:

  • Satellite cells are key targets for improving muscle healing and regeneration.
  • Therapeutic strategies involving satellite cells and scaffolds show promise for restoring muscle structure and function.
  • Minimizing scar tissue formation is critical for successful functional recovery after muscle injury.