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Related Experiment Videos

Tissue interactions in the developing chick diencephalon.

Maria Flavia Guinazu1, David Chambers, Andrew Lumsden

  • 1MRC Centre for Developmental Neurobiology, Guy's Hospital Campus, King's College, London SE1 1UL, UK. fguinazu@nimr.mrc.ac.uk

Neural Development
|November 15, 2007
PubMed
Summary
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The zona limitans intrathalamica (ZLI) forms early in vertebrate brain development. Planar signals and retinoic acid from the dorsal diencephalon are key to its positioning and extent.

Area of Science:

  • Developmental neurobiology
  • Molecular signaling in the brain

Background:

  • Vertebrate brain development relies on global gradients and local signaling centers.
  • The zona limitans intrathalamica (ZLI) is a critical organizer secreting Sonic hedgehog, essential for diencephalic subdivision.
  • Existing models of ZLI formation lack comprehensive understanding.

Purpose of the Study:

  • To investigate the roles of different forebrain regions in ZLI formation.
  • To elucidate the mechanisms underlying the establishment of the ZLI organizer.

Main Methods:

  • Tissue explant experiments in chick embryos.
  • Analysis of ZLI induction and morphogenesis.

Main Results:

  • ZLI specification occurs earlier than expected.

Related Experiment Videos

  • Flanking regions are necessary for ZLI morphogenesis.
  • ZLI induction is independent of ventral tissues and can be triggered by anterior neuroepithelial interactions.
  • Dorsal diencephalon signals, potentially retinoic acid, antagonize ZLI formation.

    • Conclusions:

    • Results support a model of planar signaling for early ZLI positioning.
    • Retinoic acid is implicated as a novel molecular cue regulating the ZLI's dorsoventral extent.