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Updated: Jul 10, 2026

An Orthotopic Sciatic Nerve Xenograft for Neurofibromatosis Type 1 Neurofibromas
Published on: October 10, 2025
Management of massive lower limb plexiform neurofibromatosis--when to intervene?
K T Power1, J Giannas, Z Babar
1Department of Plastic and Reconstructive Surgery, South Manchester University Hospital Trust, Wythenshawe, Manchester, UK.
Abstract:
Massive plexiform neurofibromatosis is an uncommon manifestation of Type 1 neurofibromatosis. These tumours result in functional disability and severe disfigurement. Due to the variable natural history od these lesions, the optimal management is not well defined and surgery is often delayed until significant disfigurement has occurred. The aim of this report is to discuss the optimum timing of surgical intervention and to highlight the difficulties in dealing with an advanced lesion.
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