Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Progressive multifocal leukoencephalopathy.

Joseph R Berger1

  • 1Department of Neurology, University of Kentucky College of Medicine, Kentucky Clinic L-445, 740 S. Limestone Street, Lexington, KY 40536-0284, USA. jrbneuro@uky.edu

Current Neurology and Neuroscience Reports
|November 15, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Financial Value of an Academic Neurologist.

Annals of neurology·2026
Same author

Uremic pancreatitis following routine initiation of losartan in advanced chronic kidney disease: A case report.

SAGE open medical case reports·2026
Same author

The Effect of Ocrelizumab on Anti-JC Virus Antibody Index.

Brain and behavior·2026
Same author

Rapidly Progressive and Relapsing Myelitis With Human T Lymphotropic Virus Type 1: A Case Report and Review of the Literature.

Neurology(R) neuroimmunology & neuroinflammation·2026
Same author

GA Depot, a long-acting glatiramer acetate, vs placebo in patients with relapsing multiple sclerosis: A randomized phase 3 clinical trial.

Multiple sclerosis (Houndmills, Basingstoke, England)·2026
Same author

Explaining the Insights Obtained from the BRANDO Database.

Arquivos de neuro-psiquiatria·2026
Same journal

Update on Genetic Chorea.

Current neurology and neuroscience reports·2026
Same journal

Gastrointestinal Dysfunction in Critically Ill Patients With Traumatic Brain Injury: Clinical Implications and Putative Mechanisms: a Narrative Review.

Current neurology and neuroscience reports·2026
Same journal

The Potential of Rehabilitation to Amplify Experience-Induced Myelin Plasticity and Remyelination in Multiple Sclerosis: A Narrative Review.

Current neurology and neuroscience reports·2026
Same journal

The Noradrenergic Brain in Parkinson's Disease.

Current neurology and neuroscience reports·2026
Same journal

Mapping the Silent Onset of Parkinson's Disease: Monoamine Imaging in the Era of the Race for Preclinical Intervention.

Current neurology and neuroscience reports·2026
Same journal

Functional and Structural Brain Imaging Correlates of Treatment Response in Functional Movement Disorder.

Current neurology and neuroscience reports·2026
See all related articles

Progressive multifocal leukoencephalopathy (PML) is a rare brain disease associated with immune deficiencies. Understanding PML pathogenesis is crucial for developing effective treatments, as current therapies are limited.

Area of Science:

  • Neurology
  • Immunology
  • Virology

Background:

  • Progressive multifocal leukoencephalopathy (PML) incidence increased with the HIV/AIDS pandemic.
  • PML has recently emerged in patients treated with natalizumab and rituximab.
  • PML is often fatal due to underlying immune deficits.

Purpose of the Study:

  • To review the current understanding of PML.
  • To discuss the implications of new PML cases in patients treated with monoclonal antibodies.
  • To explore potential therapeutic strategies based on disease pathogenesis.

Main Methods:

  • Literature review of PML cases and pathogenesis.
  • Analysis of PML emergence in patients on specific immunotherapies.
  • Discussion of JC virus and immune system interactions.

Related Experiment Videos

Main Results:

  • PML is strongly linked to immune system dysfunction.
  • Monoclonal antibodies like natalizumab and rituximab are associated with increased PML risk.
  • JC virus is the causative agent, but its reactivation is immune-dependent.

Conclusions:

  • Reversing immune deficits is key to managing PML.
  • Current treatments targeting JC virus are ineffective.
  • Further research into PML pathogenesis may yield novel therapeutic approaches.