Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Malaria

Malaria

Malaria pathogenesis in humans reflects a delicate interplay between parasite biology and host response. Clinical illness reflects a host’s immune response to the parasite’s asexual replication cycle, which is often asymptomatic in individuals with partial immunity. From the parasite's perspective, transmission between mosquito and human with minimal host pathology is evolutionarily advantageous. Among the six Plasmodium species infecting humans, P. falciparum and P. vivax dominate in global...

Migration

Migration

Migration is long-range, seasonal movement from one region or habitat to another. This common strategy, carried out by many different organisms around the world, is an adaptive response that typically corresponds to changes in an organism’s environment, like resource availability or climate. Migrations can involve huge groups of thousands of animals as well as single individuals traveling alone and can range from thousands of kilometers to just a few hundred meters.

Patterns of Fever

Patterns of Fever

Before understanding the types and patterns of fever, it is essential to know its phases.

Symbiosis

Symbiosis

Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...

Infectious Diseases and Their Occurrence

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable temporal or...

What is Climate?

What is Climate?

Climate refers to the prevailing weather conditions in a specific area over an extended period. As the saying goes, “Climate is what you expect. Weather is what you get.” Climate is influenced by geographic factors, such as latitude, terrain, and proximity to bodies of water.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Clinical, imaging and rhinoscopy findings of dogs and cats with nasal foreign bodies presenting to a UK referral hospital: 71 cases (2010-2022).

The Journal of small animal practice·2024

Same author

Unravelling the mechanisms underlying the social interaction effects on the feed efficiency of rabbits.

Animal : an international journal of animal bioscience·2024

Same author

Novel phenotypes of feeding and social behaviour and their relationship with individual rabbit growth and feed efficiency.

Animal : an international journal of animal bioscience·2024

Same author

Genomic architecture of carcass and pork traits and their association with immune capacity.

Animal : an international journal of animal bioscience·2023

Same author

Clinical presentation, diagnostic investigations, treatment protocols and outcomes of dogs diagnosed with tick-borne diseases living in the United Kingdom: 76 cases (2005-2019).

The Journal of small animal practice·2023

Same author

Short-term outcomes of chemoradiotherapy and local excision versus total mesorectal excision in T2-T3ab,N0,M0 rectal cancer: a multicentre randomised, controlled, phase III trial (the TAU-TEM study).

Annals of oncology : official journal of the European Society for Medical Oncology·2022

Search research articles

Related Experiment Video

Updated: Jul 10, 2026

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling

Published on: July 4, 2007

Shifting patterns: malaria dynamics and rainfall variability in an African highland.

M Pascual¹, B Cazelles, M J Bouma

¹Department of Ecology and Evolutionary Biology, University of Michigan, Ann Arbor, MI 48109-1048, USA. pascual@umich.edu

Proceedings. Biological Sciences

|November 15, 2007

Summary

Malaria outbreaks in East African highlands show increasing trends and epidemic sizes. Climate variability and disease dynamics interact, playing complementary roles at different scales, crucial for predictive models.

More Related Videos

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Published on: May 30, 2019

Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites

Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites

Published on: January 3, 2011

Related Experiment Videos

Last Updated: Jul 10, 2026

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling

Predicting the Effectiveness of Population Replacement Strategy Using Mathematical Modeling

Published on: July 4, 2007

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Phenotypic Analysis of Rodent Malaria Parasite Asexual and Sexual Blood Stages and Mosquito Stages

Published on: May 30, 2019

Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites

Protocol for Production of a Genetic Cross of the Rodent Malaria Parasites

Published on: January 3, 2011

Area of Science:

Epidemiology
Climate Science
Mathematical Biology

Background:

Long-term malaria patterns in East African highlands show rising cases and epidemic sizes.
The influence of climate variability on malaria epidemic cycles is debated, often contrasted with endogenous disease dynamics.

Purpose of the Study:

To investigate the interplay between climate variability and malaria dynamics in western Kenya.
To analyze long-term malaria case data and identify drivers of epidemic cycles.

Main Methods:

Utilized a time-series epidemiological model (susceptible-infected-recovered) for monthly malaria cases (1970-2003).
Employed a statistical approach for non-stationary patterns to analyze disease dynamics and climate forcing.

Main Results:

Multiyear malaria outbreak cycles emerged in the 1980s, coinciding with a regime shift in case dynamics.
Outbreaks intensified in the 1990s, with stronger coupling between malaria and rainfall, linked to increased rainfall variance.
Disease dynamics and climate forcing act complementarily across different temporal scales.

Conclusions:

Malaria epidemic cycles are driven by an interaction between disease dynamics and climate variability, not solely one or the other.
Integrating these interacting mechanisms is essential for developing accurate future malaria predictive models.