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Related Experiment Videos

Tumbling, an interactive way to move forward.

Hiroko Sano1, Sara Ricardo, Ruth Lehmann

  • 1Howard Hughes Medical Institute and the Kimmel Center for Biology and Medicine of the Skirball Institute, Department of Cell Biology, New York University School of Medicine, New York, NY 10016, USA.

Science'S STKE : Signal Transduction Knowledge Environment
|November 15, 2007
PubMed
Summary
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Drosophila border cell migration reveals novel behaviors like positional changes and tumbling. Receptor tyrosine kinases control these distinct modes via separate pathways, impacting collective cell movement.

Area of Science:

  • Developmental Biology
  • Cell Biology
  • Genetics

Background:

  • Drosophila border cells are a model for studying collective cell migration during oogenesis.
  • These cells delaminate and migrate towards the oocyte, guided by specific cues.

Purpose of the Study:

  • To investigate novel migratory behaviors of Drosophila border cells.
  • To identify the molecular mechanisms controlling these behaviors and collective cell migration.

Main Methods:

  • In vivo observation of border cell migration.
  • Genetic analysis to identify key regulatory proteins and pathways.

Main Results:

  • Two new migratory behaviors were observed: intra-cluster cell repositioning and cluster tumbling.

Related Experiment Videos

  • Receptor tyrosine kinases regulate these distinct migration modes through separate downstream pathways.
  • Early migration involves ELMO and Mbc proteins, while later migration relies on mitogen-activated protein kinase and phospholipase C-gamma signaling for cluster organization.

    • Conclusions:

    • Drosophila border cell migration exhibits complex, previously unrecognized behaviors.
    • Distinct signaling pathways downstream of receptor tyrosine kinases orchestrate different phases of collective cell migration.