Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Development: clinical and evolutionary considerations.

John M Opitz1

  • 1Department of Pediatrics (Division of Medical Genetics), University of Utah Health Sciences Center, Salt Lake City, Utah, USA. john.opitz@hsc.utah.edu

American Journal of Medical Genetics. Part A
|November 16, 2007
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Personal journeys to and in human genetics and dysmorphology.

American journal of medical genetics. Part A·2024
Same author

Evolution in the clinic: Maladaptive units and "minor anomalies".

American journal of medical genetics. Part A·2022
Same author

Living history biography: An afterthought.

American journal of medical genetics. Part A·2021
Same author

Jacqueline A. Noonan.

American journal of medical genetics. Part A·2020
Same author

An evolutionary and developmental biology approach to gastroschisis.

Birth defects research·2019
Same author

The Work of Becerra-Solano et al. (2008) on Amniotic Disruption-Adhesion-Mutilation (ADAM or DAB) Sequence Deserves Comment.

Fetal and pediatric pathology·2019
Same journal

MYH11-Related Hereditary Type 2 Visceral Myopathy in a Large Kindred: Diagnostic Odyssey With Milder Clinical Manifestations.

American journal of medical genetics. Part A·2026
Same journal

Positron Emission Tomography (PET) in Phenylketonuria: A Systematic Review of Brain Metabolism Beyond Phenylalanine.

American journal of medical genetics. Part A·2026
Same journal

Re: "Clinical Insights From a Case of Sifrim-Hitz-Weiss Syndrome With a CHD4 Variant: Expanding the Phenotypic Spectrum and Its Response to Growth Hormone Therapy".

American journal of medical genetics. Part A·2026
Same journal

Severe ADEM-Like Neuroinflammatory Disease and Cerebrovascular Fragility With Recurrent Pseudoaneurysms and Moyamoya in a Familial Germline CBL Mutation: Expanding the Clinical Phenotype.

American journal of medical genetics. Part A·2026
Same journal

Abnormal Presentation of FGFR2-Related Bent Bones Dysplasia Surviving Past the Perinatal Period in the United States.

American journal of medical genetics. Part A·2026
Same journal

Atypical Biallelic Inheritance in "Dominant" Genes: Evidence From a Large-Scale Consanguineus Exome Cohort.

American journal of medical genetics. Part A·2026
See all related articles

Molecular and morphological taxonomists collaborate to establish a natural order of life. This synthesis aids in understanding evolution, development, and the interconnectedness of species, highlighting extinction risks.

Area of Science:

  • Integrative Taxonomy
  • Evolutionary Developmental Biology
  • Conservation Biology

Background:

  • Celebration of Linnean tercentenary and M. Michael Cohen Jr.'s 70th birthday.
  • The complementary roles of molecular taxonomists and morphologists in understanding organismal relatedness.
  • Growing insights into the links between evolution and developmental processes.

Purpose of the Study:

  • To reflect on the relationship between evolution and normal/abnormal development.
  • To emphasize how understanding developmental and genetic homologies aids clinical insights.
  • To underscore the implications of evolutionary understanding for Earth's antiquity and species vulnerability.

Main Methods:

  • Integration of molecular and morphological data for phylogenetic analysis.

Related Experiment Videos

  • Ontogenetic and phylogenetic analysis of malformations.
  • Comparative studies based on homology in structure, development, and genetics.

    • Main Results:

    • Establishment of a "natural order" of living organisms based on relatedness.
    • Increased understanding of malformations through evolutionary and developmental perspectives.
    • Reinforcement of the reality of evolution and its implications for Earth's history and biodiversity.

    Conclusions:

    • The convergence of molecular and morphological approaches strengthens taxonomic understanding.
    • Evolutionary and developmental insights are crucial for clinical applications in understanding congenital anomalies.
    • Recognizing evolutionary principles highlights the fragility of species and the biosphere, including humans.