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Published on: November 15, 2017
Advantages of synthesizing trans-1,2-cyclohexanediol in a continuous flow microreactor over a standard glass
Andreas Hartung1, Mark A Keane, Arno Kraft
1Chemistry and Chemical Engineering, School of Engineering & Physical Sciences, Heriot-Watt University, Riccarton, Edinburgh EH14 4AS, United Kingdom a.kraft@hw.ac.uk.
Abstract:
Comparison is made between the preparation of trans-1,2-cyclohexanediol in standard glassware (conventional batch production) and in a microreactor (continuous flow production). The reaction sequence involved two exothermic steps where the standard procedure demands slow reagent addition and careful temperature control. In the microreactor, the reaction could be carried out safely with up to 3 times higher reagent concentration. Synthetic benefits were a faster reaction rate and a higher purity product free of colored impurities (a feature of the batch procedure).
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