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Updated: Jul 10, 2026

Generation of Chimeric Axolotls with Mutant Haploid Limbs Through Embryonic Grafting
Published on: January 29, 2020
Evidence for balancing selection at the DAB locus in the axolotl, Ambystoma mexicanum
A D Richman1, G Herrera, V H Reynoso
1Plant Sciences Department, Montana State University, Bozeman, MT 59717, USA. arichman@montana.edu
Abstract:
The axolotl (Ambystoma mexicanum) has been characterized as immunodeficient, and the absence of major histocompatibility complex (MHC) class II polymorphism has been cited as a possible explanation. Here we present evidence for considerable allelic polymorphism at the MHC class II DAB locus for a sample of wild-caught axolotls. Evidence that these sequences are the product of balancing selection for disease resistance is discussed.
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