Related Experiment Videos
Mast cell hyperplasia in atopic keratoconjunctivitis. An immunohistochemical study
S J Morgan1, J H Williams, A F Walls
1University Department of Pathology, Southampton General Hospital.
Eye (London, England)
|January 1, 1991
Abstract:
Immunohistochemical staining of conjunctival biopsies from four normal subjects and five patients with atopic keratoconjunctivitis (AKC) was performed, using a monoclonal antibody to human mast cell tryptase. A massive hyperplasia of mast cells in the patients with AKC was demonstrated. The mean mast cell density in the normal patients was 55.6/mm2 and in the patients with AKC, 172/mm2. The appearance of large numbers of mast cells in the conjunctival epithelium of AKC patients was also demonstrated. The possible pathophysiological significance of these findings is discussed.