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Related Experiment Video

Updated: Jul 10, 2026

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Comprehensive & Cost Effective Laboratory Monitoring of HIV/AIDS: an African Role Model

Published on: October 31, 2010

Cognitive function in HIV-seropositive Nigerians without AIDS.

Fatai K Salawu¹, Sunday A Bwala, Musa A Wakil

¹Department of Medicine, State Specialist Hospital, Maiduguri, Nigeria. dr_abdulsalawu@yahoo.com

Journal of the Neurological Sciences

|November 16, 2007

Summary

Cognitive function in Nigerian adults with asymptomatic HIV infection showed differences compared to HIV-negative individuals. However, CD4 cell count did not correlate with these cognitive changes.

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Area of Science:

Neuroscience
Infectious Diseases
Public Health

Background:

Cognitive impairment in HIV-positive individuals varies globally.
Limited data exists on early HIV infection's cognitive impact in developing nations, particularly Nigeria.

Purpose of the Study:

To investigate cognitive differences between asymptomatic HIV-seropositive and HIV-seronegative Nigerians.
To determine if CD4 cell count explains cognitive variations in early HIV infection.

Main Methods:

Cross-sectional study involving 60 asymptomatic, treatment-naive HIV-positive subjects and matched controls.
The Community Screening Instrument for Dementia (CSI-D) was used to assess various cognitive domains.

Main Results:

HIV-positive subjects demonstrated significant differences in language, registration, attention, calculation, orientation, and motor response compared to controls.
No significant correlation was found between CD4 cell count and cognitive test scores in HIV-positive individuals.

Conclusions:

Asymptomatic HIV infection is associated with detectable cognitive changes in Nigerian adults.
Cognitive deficits in early HIV infection are not explained by the degree of immunosuppression (CD4 count) in this population.