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Magnetic Resonance Imaging

Magnetic Resonance Imaging

Magnetic resonance imaging (MRI) is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device in clinical use by the early 1980s. The early MRI...

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Updated: Jul 10, 2026

Functional MRI in Conjunction with a Novel MRI-compatible Hand-induced Robotic Device to Evaluate Rehabilitation of Individuals Recovering from Hand Grip Deficits

Functional MRI in Conjunction with a Novel MRI-compatible Hand-induced Robotic Device to Evaluate Rehabilitation of Individuals Recovering from Hand Grip Deficits

Published on: November 23, 2019

MRI-compatible micromanipulator; design and implementation and MRI-compatibility tests.

Yoshihiko Koseki¹, Tamio Tanikawa, Kiyoyuki Chinzei

¹National Institute of Advanced Industrial Science and Technology (AIST), 1-2-1 Namiki, Tsukuba, Ibaraki, Japan.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference

|November 16, 2007

Summary

This study introduces a nonmagnetic micromanipulator for precise manipulation of microscopic objects within MRI scanners. While causing minimal MRI artifacts, its wiring significantly reduced signal-to-noise ratio.

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Area of Science:

Biomedical Engineering
Medical Imaging
Robotics

Background:

Accurate manipulation of micron-scale objects is crucial for biological and medical research.
Existing manipulation tools often interfere with sensitive Magnetic Resonance Imaging (MRI) environments.

Purpose of the Study:

To develop and evaluate an MRI-compatible micromanipulator for concurrent manipulation and observation of microscopic objects within an MRI gantry.
To assess the impact of the micromanipulator on MRI image quality and performance.

Main Methods:

Designed a nonmagnetic, electromagnetically compatible micromanipulator with a two-finger micro-hand mechanism.
Utilized piezoelectric transducers for micro-motion actuation and strain gauges for closed-loop control.
Fabricated the mechanism using acrylic plastic and a flexure parallel system.
Conducted preliminary compatibility tests with a 2-Tesla MRI scanner.

Main Results:

The micromanipulator demonstrated compatibility with the MRI, producing images comparable to those without the device.
Observed no significant image distortion, only minor artifacts attributable to the micromanipulator.
A significant decrease in MRI signal-to-noise ratio (SNR) was noted, primarily due to the micromanipulator's wiring.
Strain amplification circuits experienced voltage noise originating from the MRI.

Conclusions:

The developed micromanipulator is suitable for manipulating micron-scale objects inside an MRI scanner with minimal image distortion.
Further research is needed to mitigate the SNR degradation caused by the micromanipulator's electronic components and wiring for improved integrated performance.