Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Statistical power in single subject trials.

T Johannessen1, D Fosstvedt

  • 1Department of Community Medicine and General Practice, University of Trondheim, Norway.

Family Practice
|December 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Strong seasonality and interannual recurrence in marine myovirus communities.

Applied and environmental microbiology·2013
Same author

[Helicobacter pylori--do we know what we are doing?].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·1998
Same author

[Teaching clinical decision making in Trondheim].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·1998
Same author

On-demand therapy in gastroesophageal reflux disease: a comparison of the early effects of single doses of fast-dissolving famotidine wafers and ranitidine tablets.

Clinical therapeutics·1997
Same author

Management of peptic ulcer disease in general practice.

Scandinavian journal of primary health care·1995
Same author

[Standardized patients in general practice--a new method for quality assurance in Noway].

Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke·1995
Same journal

The Amapola Test: description of a novel screening tool for visual alterations in primary care.

Family practice·2026
Same journal

Deferred prescribing in practice: an observational study in community pharmacies in France during 2024-5 and feedback from pharmacists.

Family practice·2026
Same journal

Assessing the risk of drug-induced corrected QT interval prolongation in primary care.

Family practice·2026
Same journal

Universal-offer HIV testing amongst patients undergoing blood tests in primary care: results from a multi-centre study.

Family practice·2026
Same journal

Sustainable healthcare knowledge, experience and curricular perspectives: a cross-sectional survey within the European Young Family Doctors Movement network.

Family practice·2026
Same journal

General practice care models and satisfaction in Australian residential aged care homes: a national survey of GPs, practice nurses, and managers.

Family practice·2026
See all related articles

Controlled single-subject trials offer a structured approach to evaluating new treatments versus controls in individual patients. This method enhances therapeutic decision-making certainty compared to traditional trial-and-error practices.

Area of Science:

  • Clinical Research Methodology
  • Biostatistics
  • Pharmacological Trials

Background:

  • Individualized treatment efficacy assessment is crucial in clinical practice.
  • Traditional group-based clinical trials may not always translate to individual patient outcomes.
  • A need exists for rigorous methods to evaluate treatments in a single patient context.

Purpose of the Study:

  • To evaluate the efficacy of a new treatment compared to a control in a single patient.
  • To explore the statistical power and feasibility of controlled single-subject trials.
  • To compare the certainty of therapeutic decisions using controlled trials versus standard practice.

Main Methods:

  • A controlled single-subject trial design was employed.
  • Treatments were administered in a double-blind, randomized, multi-crossover sequence.

Related Experiment Videos

  • Statistical evaluation was based on response measures obtained from each treatment period.

    • Main Results:

    • Statistical power is influenced by sample size, response variability, treatment effect magnitude, and significance level.
    • Pairwise random allocation of treatment periods demonstrated greater statistical power than unrestricted randomization.
    • Restricted sample sizes in single-subject trials necessitate acceptance of less rigorous statistical requirements and increased risk of Type I and II errors.

    Conclusions:

    • Controlled single-subject trials provide a more certain basis for therapeutic decisions than trial-and-error methods.
    • Despite limitations in statistical rigor, these trials offer valuable insights for individual patient care.
    • Further research into optimizing single-subject trial designs is warranted.