Related Experiment Video
Updated: Jul 10, 2026

Implantation of Combined Telemetric ECG and Blood Pressure Transmitters to Determine Spontaneous Baroreflex Sensitivity in Conscious Mice
Published on: February 14, 2021
Identification of the total peripheral resistance baroreflex impulse response from spontaneous hemodynamic
Xiaoxiao Chen1, Jong-Kyung Kim, Javier A Sala-Mercado
1Department of Electrical and Computer Engineering, Michigan State University, East Lansing, MI 48824, USA. chenxia7@msu.edu
Abstract:
We have previously proposed a technique for estimating the static gain values and impulse response of the arterial and cardiopulmonary total peripheral resistance (TPR) baroreflex by mathematical analysis of beat-to-beat fluctuations in arterial blood pressure, cardiac output, and stroke volume. In this study, we evaluated the technique with respect to spontaneous hemodynamic variability measured from seven conscious dogs before and after chronic arterial baroreceptor denervation. Our results show that the technique correctly predicted the alterations in TPR baroreflex functioning that are known to occur following the baroreceptor denervation.
Related Concept Videos
Neural Regulation of Blood Pressure
Baroreceptor Reflex
Baroreceptors, located in the carotid sinuses and aortic arch, detect changes in blood pressure. When blood pressure rises, these stretch-sensitive receptors...
Autoregulation of Blood Flow
Chemical Signaling in Autoregulation
Chemical signaling operates at the precapillary sphincter level, inciting either contraction or relaxation.
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

