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Updated: Jul 10, 2026

A Computational Modeling Approach to Investigate the Influence of Hyperthermia on the Tumor Microenvironment
Published on: December 1, 2023
Immunological response induced by alternated cooling and heating of breast tumor
Jiaxiang Dong1, Ping Liu, Aili Zhang
1Department of Biomedical Engineering, School of Life Science and Technology, Shanghai Jiao Tong University, PR China.
Abstract:
A new in-situ thermal physical method combining both cryosurgery and local hyperthermia was used to treat mice bearing 4T1 murine mammary carcinoma. The induced anti-tumor immune response was investigated. The cryo/heat treatment resulted in stimulation of CTL response and attraction of immunocytes into the tumor debris, which correlated well to the tumor rejection in re-implantation. The results suggested that alternated cooling and heating had synergistic effect and might be developed into an alternative modality for tumor therapy.
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