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Developing a tissue perfusion sensor.

S L R Harvey1, K H Parker, D O'Hare

  • 1Department of Bioengineering, Imperial College London, London, UK.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
|November 16, 2007
PubMed
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A novel electrochemical sensor using a platinum ring-disc microelectrode was developed to measure tissue perfusion. This device offers continuous, cellular-level monitoring of nutrient and metabolite transport, crucial for understanding low-perfusion conditions.

Area of Science:

  • Biomedical Engineering
  • Electrochemistry
  • Physiology

Background:

  • Tissue perfusion is vital for delivering oxygen and nutrients, and removing waste products.
  • Understanding perfusion is critical in conditions like wound healing and ischemia.
  • Current methods for measuring tissue perfusion have limitations in resolution and continuity.

Purpose of the Study:

  • To develop a novel electrochemical sensor for monitoring tissue perfusion.
  • To assess the sensor's capability for continuous, cellular-level mass transport measurement.
  • To investigate the sensor's utility in low-perfusion scenarios and post-operative tissues.

Main Methods:

  • Development of a platinum/platinum ring-disc microelectrode sensor.
  • Utilizing the collector-generator principle for mass transport monitoring.

Related Experiment Videos

  • In vitro testing in free stream solutions, tissue-like media, and post-operative human tissue.

    • Main Results:

    • Demonstrated continuous monitoring of mass transport at the cellular level.
    • Achieved high spatial resolution and a wide measurement range (ml/min to microl/min).
    • Successfully tested sensor performance in various physiological and tissue-like environments.

    Conclusions:

    • The developed electrochemical sensor provides a unique capability for continuous, high-resolution tissue perfusion assessment.
    • This technology offers valuable insights into nutrient and metabolite transport, particularly in compromised tissues.
    • The sensor shows promise for clinical applications, especially in managing wounds and ischemic conditions.