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Updated: Jul 10, 2026

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An Open-Source Normothermic Perfusion System Designed for Research Scientists
Published on: July 18, 2025
Development of a new splanchnic perfusion sensor.
1School of Engineering and Mathematical Sciences, City University, London, UK. m.hickey@city.ac.uk
Summary
Continuous monitoring of splanchnic organ oxygen saturation (SpO2) aids early detection of tissue oxygenation issues. This study developed a fiber optic sensor for accurate, real-time SpO2 measurement, improving patient outcomes.
Area of Science:
- Biomedical Engineering
- Medical Devices
- Physiology
Background:
- Continuous monitoring of splanchnic organ oxygen saturation (SpO2) is crucial for early detection of inadequate tissue oxygenation.
- Failure to detect hypoperfusion can lead to severe ischemia, multiple organ failure, and mortality.
Purpose of the Study:
- To design and technically evaluate a fiber optic-based reflectance pulse oximeter sensor system for continuous splanchnic SpO2 monitoring.
- To enable intra-operative, pre-operative, and post-operative use of the sensor.
Main Methods:
- Design of a fiber optic reflectance pulse oximeter sensor and processing system.
- Investigation of optimal source-emitter spacing for the sensor.
- In vivo thermal testing of the sensor at the splanchnic tissue site.
Main Results:
- Optimal source-emitter spacing for the sensor was determined to be between 3mm and 6mm.
- In vivo thermal testing indicated insignificant temperature rise at the fiber tip, ensuring safety for splanchnic tissue.
Conclusions:
- The developed fiber optic sensor system is suitable for continuous splanchnic SpO2 monitoring.
- The sensor's design and thermal properties suggest it can be safely used in clinical settings for improved patient monitoring and outcomes.

