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A Microfluidic Chip for ICPMS Sample Introduction
Published on: March 5, 2015
PCB/polymer based micro-fluidic system for NMR spectroscopy for nanoliters sample volume
Guillaume Pasquet1, Jean-François Chateaux, Anne-Laure Deman
1Institut des Nanotechnologies de Lyon (INL), University Claude Bernard, Villeurbanne, 69622 France. guillaume.pasquet@univ-lyon1.fr
Summary
This study introduces a novel micro system for Nuclear Magnetic Resonance (NMR) spectroscopy, utilizing Printed Circuit Board (PCB) technology and a microfluidic chip for small sample volumes. The system enables precise, comparative analysis of multiple samples in a single experiment.
Area of Science:
- Analytical Chemistry
- Microfluidics
- Spectroscopy
Background:
- Nuclear Magnetic Resonance (NMR) spectroscopy traditionally requires larger sample volumes.
- Analyzing multiple samples simultaneously can enhance experimental precision and efficiency.
- Integrating microfluidic systems with NMR probes presents a challenge for miniaturization.
Purpose of the Study:
- To develop an innovative micro system for NMR spectroscopy using microfluidic technology.
- To enable NMR analysis of very small sample volumes (30-100 nL).
- To create a microfluidic chip allowing for the comparison of multiple samples within a single NMR experiment.
Main Methods:
- Fabrication of a microfluidic system using Cyclic Olefin Copolymer (COC) with two 37 nL cavities.
- Integration of the microfluidic system with a Nuclear Magnetic Resonance (NMR) probe based on Printed Circuit Board (PCB) technology.
- Demonstration of tight sealing for the microfluidic system.
Main Results:
- Successful fabrication of a dual-cavity microfluidic chip for NMR applications.
- Demonstrated tight sealing of the microfluidic system, crucial for accurate measurements.
- Presented preliminary Nuclear Magnetic Resonance (NMR) experimental results using the developed micro system.
Conclusions:
- The developed micro system, integrating PCB-based NMR probes and COC microfluidics, is a viable approach for miniaturized NMR spectroscopy.
- The dual-cavity design facilitates comparative sample analysis, enhancing precision.
- This technology holds potential for high-throughput and low-volume NMR analysis.
