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Updated: Jul 10, 2026
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The Use of Pharmacological-challenge fMRI in Pre-clinical Research: Application to the 5-HT System
Published on: April 25, 2012
Pharmacological fMRI--challenges in analysing drug-induced single-event BOLD responses
Andreas Pohlmann1, Hervé Barjat, Lorna C Tilling
1Neurology & GI Centre of Excellence in Drug Discovery, GlaxoSmithKline R&D Ltd., Harlow, CM19 5AW, UK. andreas.x.pohlmann@gsk.com
Abstract:
The interest in BOLD contrast based phMRI is likely to increase in the coming years, but detecting a direct modulation of regional brain activity by drugs presents a challenging problem. Based on in-vivo MRI and simulations we highlight some of the issues in detecting especially small BOLD signals in rat phMRI experiments.
