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Updated: Jul 10, 2026

Yeast As a Chassis for Developing Functional Assays to Study Human P53
Published on: August 4, 2019
A dynamical model on the network of p53-Mdm2 feedback loop regulated by p14/19ARF
Hui Liu1, Ying-Rong Han, Yong Zhan
1School of Science, Hebei University of Technology, Tianjin, China. lhcell@163.com
Abstract:
Base on new experimental results, we give a dynamical model to study the dynamical mechanism of the negative feedback loop composed of p53 and Mdm2 proteins regulated by p14/19ARF. The oscillatory behaviors for the activities of p53 and Mdm2 proteins regulated by p14/19ARF in individual of cells are described in our dynamical model. The results help us build a basal network about oscillatory behaviors among p53, Mdm2 and P14/19ARF. The dynamical model and its numerical results will help us understand the oscillatory behavior among other network of different proteins.
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