Efficient computer-aided detection of ground-glass opacity nodules in thoracic CT images

In this paper, an efficient compute-aided detection method is proposed for detecting Ground-Glass Opacity (GGO) nodules in thoracic CT images. GGOs represent a clinically important type of lung nodule which are ignored by many existing CAD systems. Anti-geometric diffusion is used as preprocessing to remove image noise. Geometric shape features (such as shape index and dot enhancement), are calculated for each voxel within the lung area to extract potential nodule concentrations. Rule based filtering is then applied to remove False Positive regions. The proposed method has been validated on a clinical dataset of 50 thoracic CT scans that contains 52 GGO nodules. A total of 48 nodules were correctly detected and resulted in an average detection rate of 92.3%, with the number of false positives at approximately 12.7/scan (0.07/slice). The high detection performance of the method suggested promising potential for clinical applications.