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Updated: Jul 10, 2026

Quantitative Immunofluorescence to Measure Global Localized Translation
Published on: August 22, 2017
Found in translation; from the laboratory to the operating room to the market
1Biomedical Engineering, Neurological Surgery, and Center for Technology-Guided Therapy, Vanderbilt University, Nashville, TN, USA. bob.galloway@vanderbilt.edu
Abstract:
Translation is a term, of late, frequently used in medical research. It means different things to different people. For some it is moving from conception to science and engineering to application; for others it means moving technological development into the treatment of patients; and for still others it means moving a research development into a commercial system. In 2004 in a pique of frustration with big medical device companies and academic administrators, I founded a spin-off company from my laboratory to take a development of ours to the market place. The company, Pathfinder Therapeutics Inc., as of this writing, is still in business so I presume it can be defined as a success. We have faced each of the above defined translation challenges and more remain. The presentation (and paper) will cover the process of achieving that success and of lessons often painfully learned.
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Translation
Translation is the process of synthesizing proteins from the genetic information carried by messenger RNA (mRNA). Following transcription, it constitutes the final step in the expression of genes. This process is carried out by ribosomes, complexes of protein and specialized RNA molecules. Ribosomes, transfer RNA (tRNA), and other proteins produce a chain of amino acids—the polypeptide—as the end product of translation.
Translation Produces the Building Blocks of Life
Upstream Processing
Scale-Up Processes
Production of Pharmaceuticals
Automated Microbial Diagnostics
Leaky Scanning
