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N-acetylcysteine in the prevention of contrast-induced nephropathy
1Winthrop-University Hospital, Mineola, New York 11501, USA. sfishbane@winthrop.org
Background And Objectives:
Contrast-induced nephropathy (CIN) is a common clinical problem that is growing in importance as an increasing number of tests and procedures that utilize contrast media are performed.
Design, Setting, Participants, And Measurements:
The biological and pharmacological properties of n-acetylcysteine (NAC) are reviewed, as well as the current literature relevant to the ability of NAC to prevent CIN.
Results:
After publication of a seminal study by Tepel et al. in 2000, there has been a surge in interest regarding the ability of NAC to reduce the risk for CIN. Since then a large number of studies, mostly with relatively small sample sizes, have been published.
Conclusions:
The results have been remarkably varied with some studies finding great efficacy with NAC but most finding no significant benefit.
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