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Association of serum uric acid level and coronary blood flow

Ali Yildiz1, Remzi Yilmaz, Recep Demirbag

  • 1Department of Cardiology, Harran University, School of Medicine, Sanliurfa, Turkey. ghcayildiz@yahoo.com

Coronary Artery Disease
|November 16, 2007
PubMed

Insights

Elevated serum uric acid levels are significantly associated with slow coronary flow (SCF). Higher uric acid may independently predict the presence of SCF, indicating its role in coronary artery disease.

Area of Science:

  • Cardiology
  • Biochemistry
  • Vascular Biology

Background:

  • Slow coronary flow (SCF) is linked to endothelial dysfunction and atherosclerosis.
  • Serum uric acid is a marker for atherosclerosis, oxidative stress, and endothelial dysfunction.

Purpose of the Study:

  • To investigate the association between coronary blood flow and serum uric acid levels.
  • To compare serum uric acid and other laboratory parameters in patients with SCF versus controls.

Main Methods:

  • Quantified coronary blood flow using thrombolysis in myocardial infarction frame count (TFC).
  • Measured serum uric acid levels in 64 SCF patients and 369 controls.
  • Evaluated associations between TFC, serum uric acid, and clinical/laboratory parameters.

Main Results:

  • SCF patients had significantly higher serum uric acid, hemoglobin, heart rate, and prevalence of smoking compared to controls.
  • Mean TFC correlated significantly with serum uric acid, urea, creatinine, HDL-cholesterol, hemoglobin, platelet count, male gender, smoking, heart rate, and systolic blood pressure.
  • Serum uric acid, heart rate, and smoking were independent predictors of SCF; serum uric acid was the sole independent predictor of mean TFC.

Conclusions:

  • Serum uric acid level is significantly associated with coronary blood flow.
  • Elevated serum uric acid may be an independent predictor for the presence of slow coronary flow.
Abstract

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