Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Long-term Potentiation01:35

Long-term Potentiation

51.6K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
51.6K
Long-term Depression01:05

Long-term Depression

27.3K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
27.3K
Long-term Potentiation01:25

Long-term Potentiation

2.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
2.7K
Long-term Depression01:03

Long-term Depression

2.6K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
2.6K
Plasticity00:58

Plasticity

2.2K
Plasticity is the property where an object loses its elasticity and undergoes irreversible deformation, even after the deformation forces are eliminated. If a material deforms irreversibly without increasing stress or load, then this is called ideal plasticity. For example, when a force is applied to an aluminum rod, it changes its shape, but it does not return to its original shape once the force is removed. Plastic deformation or ductility is thus a permanent deformation or change in the...
2.2K
Neuroplasticity01:01

Neuroplasticity

2.6K
Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Love, death, and oxytocin: In memory of Larry Young.

Progress in neurobiology·2026
Same author

Oxytocin selectively biases sensory-prefrontal communication through network-level suppression and theta coupling.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Activity-dependent protein synthesis in neurons requires microglial-metabolic coupling.

Cell metabolism·2026
Same author

A collicular-hypothalamic pathway for social visual awareness.

bioRxiv : the preprint server for biology·2026
Same author

Integrin-deficient T cell leukemia accumulates in the central nervous system.

bioRxiv : the preprint server for biology·2026
Same author

Sex differences in neuromodulatory subcortical systems and their implications for Alzheimer's disease.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same journal

Six ways to put the public at the heart of science and policy.

Nature·2026
Same journal

The complex truth about trust in science.

Nature·2026
Same journal

Have people stopped trusting science? The data tell a surprising story.

Nature·2026
Same journal

How FAIR data are helping to build trust in science.

Nature·2026
Same journal

Scientists should recognize their own political biases to build public trust.

Nature·2026
Same journal

Harmonizing standards and resources for the medical genome.

Nature·2026
See all related articles

Related Experiment Video

Updated: May 2, 2026

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

18.3K

A synaptic memory trace for cortical receptive field plasticity.

Robert C Froemke1, Michael M Merzenich, Christoph E Schreiner

  • 1Coleman Memorial Laboratory and W. M. Keck Foundation Center for Integrative Neuroscience, Department of Otolaryngology, University of California, San Francisco, California 94143, USA. rfroemke@phy.ucsf.edu

Nature
|November 16, 2007
PubMed
Summary
This summary is machine-generated.

The cholinergic nucleus basalis rapidly reshapes auditory cortex receptive fields by transiently reducing inhibition, followed by excitation. This plasticity, crucial for learning, persists for hours, creating a lasting memory trace.

More Related Videos

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.5K
Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

806

Related Experiment Videos

Last Updated: May 2, 2026

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity
11:56

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

18.3K
Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording
14:27

Investigating Long-term Synaptic Plasticity in Interlamellar Hippocampus CA1 by Electrophysiological Field Recording

Published on: August 11, 2019

12.5K
Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus
05:01

Inducing Long-Term Plasticity of Intrinsic Neuronal Excitability in Neurons of the Dorsal Lateral Geniculate Nucleus

Published on: September 20, 2024

806

Area of Science:

  • Neuroscience
  • Auditory Cortex Plasticity
  • Synaptic Plasticity

Background:

  • Cortical receptive fields are plastic and change with neural activity and experience.
  • Neuromodulation is essential for cortical plasticity, but subcortical system interactions are unclear.

Purpose of the Study:

  • To investigate the dynamics of synaptic receptive field plasticity in the adult primary auditory cortex (AI).
  • To understand how the nucleus basalis modulates auditory cortical circuits.

Main Methods:

  • In vivo whole-cell recordings in the adult primary auditory cortex (AI).
  • Pairing sensory stimulation with nucleus basalis activation.

Main Results:

  • Nucleus basalis activation rapidly reduced synaptic inhibition within seconds, followed by excitation specific to the paired stimulus.
  • Receptive field reorganization continued for hours after brief nucleus basalis stimulation.
  • Inhibition slowly increased to rebalance excitation, creating a new stimulus preference.

Conclusions:

  • A transient period of disinhibition is a key mechanism for receptive field plasticity.
  • This process may form a memory trace for behaviorally significant stimuli.