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Updated: Jul 10, 2026

A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
[Diagnosis of hemangiomas and vascular malformations: an overview]
1Department of Oral and Maxillofacial Surgery, College of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, China. ms_yxj@126.com
Abstract:
Hemangiomas and vascular malformations are the most common vascular lesions in infants and children. In the past years, due to the lack of definite classification and distinctions of vascular lesions, misdiagnosis and mismanagement were often encountered and the patients underwent inappropriate treatment. A renaissance began with the biological classification proposed by Mulliken and Glowacki in 1982. They categorized vascular lesions into hemangiomas and vascular malformations, which were absolutely different both clinically and biologically. Hemangiomas are benign tumors of infancy that have a proliferation phase followed by subsequent involution throughout childhood. Vascular malformations result from errors of vascular morphogenesis, they grow commensurate with the patient throughout life and never involute. From a prognostic standpoint, vascular malformations may need intervention as early as possible. So we must differentiate hemangiomas from vascular malformations early and accurately. In this review, we summarize the highlights of the diagnosis between hemangiomas and vascular malformations. Supported by Shanghai Leading Academic Discipline Project (Grant No.Y0203).
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