Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Antithrombin III in liver disorders.

S Sundar1, R K Mall, B Dube

  • 1Department of Medicine, Banaras Hindu University, Varanasi.

The Journal of the Association of Physicians of India
|July 1, 1991
PubMed
Summary

Antithrombin III levels, both biological and immunological, are significantly reduced in patients with viral hepatitis and liver cirrhosis. Immunological activity correlates with liver function, suggesting prognostic value in hepatitis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CBCT-Guided Pencil Beam Scanning Proton Therapy for Moving Lung Tumours: PROMO Study- Standardised Workflow and Early Outcomes From a Consecutive Real-World Cohort.

Clinical oncology (Royal College of Radiologists (Great Britain))·2026
Same author

Deep Architectures Fail to Generalize: A Lightweight Alternative for Agricultural Domain Transfer in Hyperspectral Images.

Sensors (Basel, Switzerland)·2026
Same author

Synergistic associations of ambient air pollution and heat on daily mortality in India.

Environment international·2025
Same author

The chromatin landscape of high-grade serous ovarian cancer metastasis identifies regulatory drivers in post-chemotherapy residual tumour cells.

Communications biology·2024
Same author

Bladder trigone sparing radiotherapy in prostate cancer treatment.

Radiography (London, England : 1995)·2024
Same author

ESGO-ESMO-ESP consensus conference recommendations on ovarian cancer: pathology and molecular biology and early, advanced and recurrent disease.

Annals of oncology : official journal of the European Society for Medical Oncology·2024

Area of Science:

  • Hepatology
  • Clinical Biochemistry
  • Immunology

Background:

  • Antithrombin III (ATIII) is a crucial anticoagulant protein.
  • Liver disease can impact the synthesis and function of plasma proteins.
  • The role of ATIII in viral hepatitis and cirrhosis requires further elucidation.

Purpose of the Study:

  • To investigate biological and immunological antithrombin III activity in patients with viral hepatitis and liver cirrhosis.
  • To assess the correlation between ATIII activity and liver function markers.
  • To determine the prognostic value of ATIII in hepatitis.

Main Methods:

  • Studied 26 patients with viral hepatitis (6 with encephalopathy) and 11 with liver cirrhosis.
  • Measured biological and immunological antithrombin III activity.
  • Correlated ATIII activity with SGOT/SGPT and serum bilirubin levels.

Main Results:

  • Significant reduction in both biological and immunological ATIII activity observed in all liver disorder groups.
  • Good correlation between biological and immunological ATIII activity (P < 0.05).
  • Significant inverse correlation between immunological ATIII activity and SGOT/SGPT (P < 0.01) and serum bilirubin (P < 0.001).
  • Biological ATIII activity showed no relation to hepatic enzymes or bilirubin.
  • ATIII levels declined proportionally with hepatic necrosis, likely due to reduced synthesis.

Conclusions:

  • Antithrombin III deficiency is present in viral hepatitis and liver cirrhosis.
  • Immunological ATIII activity serves as a valuable prognostic marker in hepatitis, correlating with liver dysfunction.
  • Reduced ATIII synthesis is implicated in the decline of its levels during severe liver disease.

Related Experiment Videos