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Updated: Jul 10, 2026
10:42
Generation and Culturing of Primary Human Keratinocytes from Adult Skin
Published on: December 22, 2017
Keratin and filaggrin expression in keratoacanthoma
Yoshiyuki Ito1, Ichiro Kurokawa, Keisuke Nishimura
1Department of Dermatology, Mie University Graduate School of Medicine, Tsu, Japan.
Journal of the European Academy of Dermatology and Venereology : JEADV
|November 17, 2007
Summary
Keratoacanthoma (KA) differentiation was studied using keratin expression. Results suggest KA originates from the outer root sheath beneath the sebaceous duct opening.
Area of Science:
- Dermatopathology
- Molecular Biology
- Histogenesis
Background:
- Keratoacanthoma (KA) is a common skin tumor.
- Its precise histogenesis remains incompletely understood.
- Understanding KA origin is crucial for diagnosis and treatment.
Purpose of the Study:
- To investigate the cellular origin and differentiation pathway of keratoacanthoma.
- To analyze keratin expression patterns in KA tissue.
- To elucidate the histogenesis of KA by examining specific keratin markers.
Main Methods:
- Immunohistochemical analysis of 10 keratin antibodies (K1, K7, K8, K10, K14, K15, K16, K17, K18, K19).
- Use of an anti-filaggrin antibody.
- Examination of keratin expression in the central region of KA lesions.
Main Results:
- Reduced expression of K1 and K10 in the center of KA.
- Detection of K14 and K16 in KA tumor cells.
- Expression patterns suggest differentiation towards the outer root sheath.
Conclusions:
- Keratoacanthoma likely originates from the outer root sheath.
- The differentiation pathway involves specific keratin expression changes.
- Findings clarify the histogenesis of keratoacanthoma.
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