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Updated: Jul 10, 2026

Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)
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Identifying Dysregulated Genes Induced by Kaposi's Sarcoma-associated Herpesvirus (KSHV)

Published on: September 14, 2010

Septic illness and Kaposi's sarcoma.

Jessica Daniel1, Andrew Shaw

  • 1Department of Genitourinary Medicine, Northwick Park Hospital, Harrow, Middlesex, UK. jessica.daniel@st-marys.nhs.uk

International Journal of STD & AIDS
|November 17, 2007
PubMed
Summary

Disseminated Kaposi's sarcoma (KS) can mimic sepsis, presenting without typical skin lesions. Autopsy revealed widespread KS in two cases with minimal skin involvement, highlighting a rare diagnostic challenge.

Area of Science:

  • Oncology
  • Pathology
  • Infectious Disease

Background:

  • Kaposi's sarcoma (KS) is an opportunistic malignancy often associated with Human Immunodeficiency Virus (HIV).
  • Typical KS presentation involves characteristic mucocutaneous lesions.
  • Diagnosis usually relies on clinical examination and biopsy of skin lesions.

Observation:

  • Two cases presented with symptoms mimicking severe sepsis.
  • Neither case initially showed typical cutaneous or mucosal lesions of Kaposi's sarcoma.
  • Extensive internal organ involvement was discovered during postmortem examination.

Findings:

  • Postmortem analysis confirmed disseminated Kaposi's sarcoma as the underlying cause of illness.
  • The absence of significant skin lesions in these cases represents an atypical presentation.

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  • Internal organ infiltration by KS was extensive, leading to systemic illness.

    • Implications:

    • This presentation underscores the importance of considering disseminated KS in patients with sepsis-like symptoms, even without visible skin lesions.
    • Diagnostic protocols may need to be broadened to include KS in differential diagnoses for severe systemic illness.
    • Further research into atypical KS presentations is warranted to improve early diagnosis and patient outcomes.