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Updated: Jul 10, 2026
Detection of Inflammasome Activation and Pyroptotic Cell Death in Murine Bone Marrow-derived Macrophages
Published on: May 21, 2018
Rebuilding host-pathogen interaction from the ground up: in vitro reconstitution of the inflammasome
Joseph A Duncan1, Jenny Pan-Yun Ting
1Department of Medicine, Division of Infectious Diseases, University of North Carolina at Chapel Hill, UNC-CH, Chapel Hill, NC 27599-7295, USA. joseph_duncan@med.unc.edu
Abstract:
The inflammasome is a macromolecular complex responsible for the proteolytic processing and activation of the secreted cytokine IL-1beta. It is assembled and activated in response to upstream intracellular sensors of microbial components and cell injury. Now, Faustin et al. describe an in vitro cell-free reconstitution of the inflammasome, opening up a new avenue to better understand this innate immune pathway of microbe sensing.
